The effect of repeated lipopolysaccharide endotoxin challenge on immune response of breeding ewes and subsequent lamb performance.

Infectious disease caused by exposure to Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is recognized to suppress female fertility. However, the effect of varying low-dose endotoxin exposure during distinct stages of follicle development on immune response, reproductive performance, and lamb performance has yet to be elucidated. Therefore, the objective of this study was to evaluate acute phase response, mRNA abundance of inflammatory markers, reproductive performance and lamb growth characteristics of ewes challenged with subclinical doses of LPS.

Cognitive Performance of Latino and White Non-Latino Individuals With Parkinson's Disease.

Objective: Cognitive impairment is a common nonmotor symptom in Parkinson's disease (PD). Individuals of Latino background are traditionally underrepresented in research on PD. Despite the fact that Latinos comprise 18% of the U.

Diesel exhaust particle extract elicits an oxPAPC-like transcriptomic profile in macrophages across multiple mouse strains.

Air pollution is a prominent cause of cardiopulmonary illness, but uncertainties remain regarding the mechanisms mediating those effects as well as individual susceptibility. Macrophages are highly responsive to particles, and we hypothesized that their responses would be dependent on their genetic backgrounds. We conducted a genome-wide analysis of peritoneal macrophages harvested from 24 inbred strains of mice from the Hybrid Mouse Diversity Panel (HMDP).

The power of us: breaking barriers and bridging the gap of ultrasound in rheumatology to empower a new generation.

Objective: This study assesses musculoskeletal ultrasound (MSUS) knowledge, attitudes, and practices among young rheumatologists in Mexico, aiming to identify barriers and facilitators to its clinical use.

Methods: An online survey distributed to a network of young rheumatologists captured demographics, institutional, and personal MSUS information. Multivariable analysis identified factors associated with positive MSUS attitudes.

Limited Independent Follow-Up with Germline Testing of Variants Detected in and by Tumor-Only Sequencing.

Introduction: Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator. However, because many of the genes analyzed on tumor profiling overlap with those known to be associated with hereditary cancer predisposition syndromes (HCPS), tumor-only profiling can unknowingly uncover germline pathogenic (P) and likely pathogenic variants (LPV). In this study, we evaluated the number of patients with P/LPVs identified in and () via tumor-only profiling, then determined the germline testing outcomes for those patients.

Sinc method for generating and extending phase screens of atmospheric turbulence.

We present a method, based on sinc series approximation, for generating and extending phase screens of atmospheric turbulence in real time to arbitrary lengths. Unlike phase screen representations based on the Fourier series, the sinc approximation is naturally suited to problems on infinite domains and thus avoids the problem of artificial periodicity inherent in the Fourier series. In particular, phase screens generated using the sinc method have accurate non-periodic statistics throughout the computational domain.

Do pictures influence memory and metamemory in Chinese vocabulary learning? Evidence from Russian and Colombian learners.

Despite the increasing interest in learning non-alphabetical languages such as Chinese, research about its learning process for alphabet users is scarce. Research conducted on Latin alphabet users on learning languages written in Latin alphabet, or on Chinese language learning in Chinese native speakers, users is undoubtedly useful but it does not inform about the peculiarities of leaning Chinese language by other alphabet users. Additionally, several authors have highlighted the need to inform and extend the current second language acquisition theories on the particular challenges of learning a language that uses another script.

Conversational pragmatics: memory reporting strategies in different social contexts.

Previous studies in conversational pragmatics have showed that the information people share with others heavily depends on the confidence they have in the correctness of a candidate answer. At the same time, different social contexts prompt different incentive structures, which set a higher or lower confidence criterion to determine which potential answer to report. In this study, we investigated how the different incentive structures of several types of social contexts and how different levels of knowledge affect the amount of information we are willing to share.

Letter Spacing Does not Affect Memory and Metamemory.

Some perceptual manipulations, such as font size or bolding, can affect the estimations of future memorability (i.e., judgments of learning or JOLs).

Synergistic associations of depressive symptoms and aging on cognitive decline in early Parkinson's disease.

Objective: Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder. About 40%-50% of PD patients experience depression, making it one of the most common neuropsychiatric disturbances in PD. Cognitive deficits (e.

Is There an Early Morphological Decomposition during L2 Lexical Access? A Meta-Analysis on the Morphological Priming Effect.

A considerable body of experimental data currently exists on the representation and processing of derived words. However, no theoretical account has led to a consensus so far, due in part to inconsistencies in empirical results which show either the presence or the absence of signs of early morphological decomposition during lexical access. In this paper, we present the results of a meta-analysis that sought to examine the robustness of the masked morphological priming effect (MMP) in native and non-native speakers.

Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline.

Introduction: According to the Movement Disorder Society (MDS), subjective cognitive complaints (SCC) are a diagnostic criterion for PD-mild cognitive impairment (PD-MCI); however, studies often do not incorporate SCC when classifying PD-MCI. This inconsistent use may reflect mixed findings regarding the association between SCC and objective measures of cognitive impairment. Our study aimed to describe the extent that inclusion/exclusion of SCC affects the occurrence of PD-MCI, and if the inclusion of SCC is associated with faster cognitive decline and cerebrospinal fluid markers (CSF) of alpha-synuclein, amyloid beta, total tau, and phophorylated-tau.

Do Beliefs About Font Size Affect Retrospective Metamemory Judgments in Addition to Prospective Judgments?

Beliefs about how memory works explain several effects on prospective metamemory judgments (e.g., the effect of font size on judgments of learning; JOLs).

Frequency of Course Remediation and the Effect on North American Pharmacist Licensure Examination Pass Rates.

Remediation is a tool that allows students to correct an academic deficiency after earning an unsatisfactory grade. There is a lack of data on remediation processes and their impact on future academic performance. This study aimed to evaluate the impact of remediation frequency on North American Pharmacist Licensure Examination (NAPLEX) performance.

Monitoring and control processes in mock witnesses in under-represented non-WEIRD samples with high or low educational level.

A popular model proposes that metamemory is based on two processes, monitoring and control. The first examines memories and evaluates their quality and the second uses that information to decide on the most appropriate course of action. Monitoring and control processes have been studied mostly with university students, which raises the question of how well do they work in groups of people from under-represented samples such as people with a low educational level.

Ancient DNA and deep population structure in sub-Saharan African foragers.

Multiple lines of genetic and archaeological evidence suggest that there were major demographic changes in the terminal Late Pleistocene epoch and early Holocene epoch of sub-Saharan Africa. Inferences about this period are challenging to make because demographic shifts in the past 5,000 years have obscured the structures of more ancient populations. Here we present genome-wide ancient DNA data for six individuals from eastern and south-central Africa spanning the past approximately 18,000 years (doubling the time depth of sub-Saharan African ancient DNA), increase the data quality for 15 previously published ancient individuals and analyse these alongside data from 13 other published ancient individuals.

The mechanisms underlying grammatical gender selection in language production: A meta-analysis of the gender congruency effect.

Grammatical gender retrieval during language production has been largely addressed through the picture-word interference (PWI) paradigm, with the aim of capturing the so-called gender congruency effect (GCE). In the PWI paradigm, participants name target pictures while ignoring superimposed written distractor nouns. The GCE shows faster responses when target and distractor nouns share the same gender than when gender differs.

Optimization of a Loop-Mediated Isothermal Amplification Assay as a Point-of-Care Tool for the Detection of in Human Blood in Tana River Delta, Kenya.

Introduction: Accurate detection of filarial parasites in humans and vectors is essential for the implementation and evaluation of Global and National Programs to eliminate lymphatic filariasis. Immunological methods to detect infection are available; however, cross-reactivity issues have been reported in most of them. Nucleic acid-based molecular assays offer high levels of specificity and sensitivity and can be used to detect the infections.

Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers.

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Towards a rigorous understanding of societal responses to climate change.

A large scholarship currently holds that before the onset of anthropogenic global warming, natural climatic changes long provoked subsistence crises and, occasionally, civilizational collapses among human societies. This scholarship, which we term the 'history of climate and society' (HCS), is pursued by researchers from a wide range of disciplines, including archaeologists, economists, geneticists, geographers, historians, linguists and palaeoclimatologists. We argue that, despite the wide interest in HCS, the field suffers from numerous biases, and often does not account for the local effects and spatiotemporal heterogeneity of past climate changes or the challenges of interpreting historical sources.

Antibiofilm Activity of Acidic Phospholipase Isoform Isolated from Snake Venom.

Introduction: Bacterial resistance is a worldwide public health problem, requiring new therapeutic options. An alternative approach to this problem is the use of animal toxins isolated from snake venom, such as phospholipases A (PLA), which have important antimicrobial activities. is one of the snake species in the northeast of Brazil that attracts great medical-scientific interest.

Bothrops erythromelas venom and its action on isolated murine macrophages.

Snakebite is a universally neglected public health problem. It victimizes approximately 2.5 million people annually and kills around 125 thousand.