cytogenetic abnormalities can be detected in multiple myeloma by imaging flow cytometry.

Aims: Cytogenetic abnormalities involving the gene are seen in up to 55% of patients with multiple myeloma. Current testing is performed manually by fluorescence hybridisation (FISH) on purified plasma cells. We aimed to assess whether an automated imaging flow cytometric method that uses immunophenotypic cell identification, and does not require cell isolation, can identify abnormalities.