Telehealth in emergency medicine residency training: A model curriculum.

Emergency physicians are well-positioned to take a leadership role in telehealth, particularly in emerging categories such as triage, direct acute unscheduled care, and virtual observation. However, the growth of telehealth has outpaced curricular development in emergency medicine (EM) residency programs. This manuscript presents a model longitudinal telehealth curriculum, developed by the consensus of education experts, including representatives from the telehealth interest groups from EM's two primary specialty societies: the American College of Emergency Physicians and the Society for Academic Emergency Medicine.

Multidisciplinary treatment approach for complex crown-root fractures in child with periodontal health as the guiding principle: a case report with 8-year follow-up.

Background: Pediatric anterior teeth complex crown-root fractures has high incidence and pose greater treatment challenges. Dynamic tooth development increases risks for orthodontic, periodontal, and restorative treatments.

Case Description: The authors present a case of a 12-year-old boy with a complex crown-root fracture in the right maxillary central incisor.

Enhanced recovery after surgery pathway reduces back pain, hospitalization costs, length of stay, and satisfaction rate of lumbar tubular microdiscectomy: A retrospective cohort study.

Tubular microdiscectomy is one of the most commonly performed surgical procedures for lumbar disc herniation (LDH). This study aimed to investigate the effectiveness of the enhanced recovery after surgery (ERAS) pathway for microdiscectomy in improving perioperative clinical outcomes in patients with LDH. This study retrospectively analyzed the prospectively collected perioperative outcomes of patients in pre-ERAS (January 2020 to December 2021) and post-ERAS (January 2022 to September 2023) groups.

Regulation of TS-1 Zeolite with Small Particle Size by Colloidal Silicon Seed-Induced Synthesis and Application in Oxidative Desulfurization.

The dosages of colloidal silicon seeds in the seed-induced synthesis of TS-1 zeolites were investigated in detail. The characterization results revealed that the colloidal silicon seeds not only reduced the particle sizes but also promoted the incorporation of titanium atoms into the framework of TS-1 zeolites as prepared. SEM images and particle size distribution (PSD) confirmed that the particle sizes of TS-1 zeolite could be effectively reduced to about 150 nm.

CFEM Proteins Suppress Host Immunity and Differentially Contribute to Virulence.

The pathogen is responsible for the devastating pokkah boeng disease, which causes significant economic losses in sugarcane production. However, the mechanisms by which it affects plant immunity remain largely unknown. Common in Fungal Extracellular Membrane (CFEM) domain proteins have been implicated in fungal growth, infection processes, and pathogenicity.

Clearing MRD positivity with blinatumomab in pediatric B-cell acute lymphoblastic leukemia: insights from droplet digital PCR and flow cytometry.

Blinatumomab has shown to improve survival outcomes in B-cell acute lymphoblastic leukemia (B-ALL) patients with measurable residual disease (MRD) detected by multiparametric flow cytometry (MFC). However, data on blinatumomab clearing MRD with high sensitivity remain scarce. This study evaluates the effectiveness of blinatumomab in eradicating low levels of MRD, as detected by droplet digital PCR (ddPCR) but undetectable by MFC, in children with B-ALL.

An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure.

Background: A proportion of individuals exposed to respiratory viruses avoid contracting detectable infection. We tested the hypothesis that early innate immune responses associate with resistance to detectable infection in close contacts of COVID-19 cases.

Methods: 48 recently-exposed household contacts of symptomatic COVID-19 cases were recruited in London, UK between May 2020 and March 2021 through a prospective, longitudinal observational study.

Multi-gradient energy-saving smart windows with thermo-response and multimodal thermal energy storage.

Buildings, especially installed windows, account for a large proportion of global energy consumption. The research trend of smart windows leans towards multi-functional integration, concurrently achieving solar modulation and thermal management. However, sometimes a one-time performance switch cannot meet demands, making the design of multi-gradient adjustable smart windows particularly important.

Precision-engineered PROTACs minimize off-tissue effects in cancer therapy.

Proteolysis-targeting chimeras (PROTACs) offer a groundbreaking approach to selectively degrade disease-related proteins by utilizing the ubiquitin-proteasome system. While this strategy shows great potential in preclinical and clinical settings, off-tissue effects remain a major challenge, leading to toxicity in healthy tissues. This review explores recent advancements aimed at improving PROTAC specificity, including tumor-specific ligand-directed PROTACs, pro-PROTACs activated in tumor environments, and E3 ligase overexpression strategies.

Chemical looping ammonia synthesis based on the self-carried active N and Al from aluminum dross as low-cost nitrogen carrier.

Ammonia (NH), as a hydrogen energy carrier, is advantageous for mitigating energy consumption and carbon emission; however, the current Haber process for NH synthesis requires harsh conditions with a low conversion rate. To address these challenges, chemical looping ammonia synthesis (CLAS) has been proposed for utilizing aluminum dross (AD)-a hazardous waste containing sufficient active Al and N as a nitrogen carrier-involving carbon conversion without emissions. AD samples were employed to investigate the performance of CLAS, and the evolution of nitrogen carrier.

Genome‑wide identifcation and expression analysis of growth-regulating factors under drought in Brassica juncea.

Growth-regulating factors (GRFs) are plant-specific transcription factors involved in the regulation of plant growth, development, and abiotic stress processes. However, the function of Brassica juncea (L.) Czern & Coss GRFs remain largely unknown.

BMSMM-Net: A Bone Metastasis Segmentation Framework Based on Mamba and Multiperspective Extraction.

Rationale And Objectives: Metastatic bone tumors significantly reduce patients' quality of life and expedite cancer spread. Traditional diagnostic methods rely on time-consuming manual annotations by radiologists, which are prone to subjectivity. Employing deep learning for rapid, precise segmentation of bone metastases can greatly improve patient outcomes and survival.

LncRNA H19 improves mesenchymal characteristics of buffalo (Bubalus bubalis) bone marrow-derived mesenchymal stem cells under hypoxic conditions.

As adult stem cells with various advantages, Bone marrow-derived mesenchymal stem cells (BMSCs) are valuable resources for veterinary treatment and animal reproduction. Previous studies have shown that hypoxia can induce epithelial-mesenchymal transition (EMT) and improve mesenchymal characteristics of BMSCs in vitro culture. However, the mechanism by which hypoxia improves the interstitial characteristics of buffalo BMSCs (bBMSCs) remains unclear.

Optimization of Communication Signal Adversarial Examples by Selectively Preserving Low-Frequency Components of Perturbations.

Achieving high attack success rate (ASR) with minimal perturbed distortion has consistently been a prominent and challenging research topic in the field of adversarial examples. In this paper, a novel method to optimize communication signal adversarial examples is proposed by focusing on low-frequency components of perturbations (LFCP). Observations on model attention towards DCT coefficients reveal the crucial role of LFCP within adversarial examples in altering the model's predictions.

Effector FsMEP1 Contributes to Virulence by Disturbing Localization of Thiamine Thiazole Synthase ScTHI2 from Sugarcane.

is a significant pathogenic fungus that causes sugarcane Pokkah Boeng. Proteins secreted by pathogenic fungi can be delivered into hosts to suppress plant immunity and establish infection. However, there is still much to be discovered regarding 's secreted effectors in overcoming plant immunity.

Macroporous resins combined with UPLC-QTRAP-MS/MS for the purification and identification of 3-deoxyanthocyanidins from Sorghum bicolor L. Moench and their bioactivities.

3-Deoxyanthocyanidins (3-DAS) are the unique flavonoid compounds in sorghum. The majority of research to date have concentrated on the biological activity and extraction of 3-DAS from sorghum and lacked systematic purification and identification investigations. Herein, a facile method for the purification of sorghum 3-DAS from the acidic methanol solution crude extract using macroporous resins (MARs) was proposed and investigated in this work.

Association between dietary inflammatory index and adolescent myopia based on the National Health and Nutrition Examination Survey.

The prevalence of adolescent myopia is remarkably increasing. Previous studies have indicated that an unhealthy diet is a risk factor for myopia. However, the link between diet-related inflammation and myopia is unclear.

Intrinsic PD-L1 Degradation Induced by a Novel Self-Assembling Hexapeptide for Enhanced Cancer Immunotherapy.

Programmed death-ligand 1 (PD-L1) is a critical immune checkpoint protein that facilitates tumor immune evasion. While antibody-based PD-1/PD-L1 inhibitors have shown promise, their limitations necessitate the development of alternative therapeutic strategies. This work addresses these challenges by developing a hexapeptide, KFM (Lys-Phe-Met-Phe-Met-Lys), capable of both directly downregulating PD-L1 and self-assembling into a ROS-responsive supramolecular hydrogel.

High-Performance GaO Solar-Blind Photodetector Based on Thermal Oxidized Ga Buffer-Layer.

High-performance GaO solar-blind photodetectors are critical for applications due to their selective solar-blind ultraviolet sensitivity. The quality of the GaO film has a significant impact on the performance of photodetectors. This study presents an innovative approach to enhancing the quality of GaO films through the introduction of a naturally graded buffer layer, which is formed by the oxidation of a metallic Ga film and significantly improves interface stability by accommodating lattice mismatches and reducing defects.

The mediating effect of advanced health assessment on the relationship between self-directed learning and clinical thinking among master of nursing specialist postgraduate students: A structural equation model.

Background: Clinical thinking is an important competency among master of nursing specialist (MNS) postgraduate students. Previous studies have demonstrated that self-directed learning (SDL) positively affects clinical thinking among MNS postgraduates. However, little is known about the mechanisms underlying the relationship between SDL and clinical thinking.

Comparative analysis of gut microbiota in incident and prevalent peritoneal dialysis patients with peritoneal fibrosis, correlations with peritoneal equilibration test data in the peritoneal fibrosis cohort.

Introduction: The connection between peritoneal function and gut microbiota in peritoneal fibrosis (PF) patients remains uncertain.

Methods: Peritoneal equilibration test (PET) was employed to evaluate peritoneal function in patients with peritoneal fibrosis (PF). 16S rRNA sequencing was used to analyze the gut flora in incident peritoneal dialysis (PD) and PF groups, identifying differential microbial communities.

Rolling-Translated circRUNX2.2 Promotes Lymphoma Cell Proliferation and Cycle Transition in Marek's Disease Model.

Marek's disease (MD), an immunosuppressive disease induced by the Marek's disease virus (MDV), is regarded as an ideal model for lymphoma research to elucidate oncogenic and anti-oncogene genes. Using this model, we found that circRUNX2.2, derived from exon 6 of RUNX2, was significantly upregulated in MDV-infected tumorous spleens.