Publications by authors named "Lulu Gao"

Background: The incidence of non-tuberculous mycobacteria (NTM) has been rising globally, posing significant challenges for diagnosis and treatment, particularly in regions with high tuberculosis (TB) incidence. This study aims to investigate the epidemiological, demographic, and clinical characteristics of non-tuberculous mycobacterial lung disease (NTM-PD) in areas with a high incidence of TB.

Method: This study was conducted at the Affiliated Hospital of Zunyi Medical University from January 2017 to December 2021.

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Foxtail millet (Setaria italica) is one of the most ancient cultivated cereal crops and is ideal for the functional genomics of the Panicoideae crops. In the present study, we generated an F population consisting of 300 individuals by crossing an elite foxtail millet variety Jingu28 with a backbone line Ai88, and constructed a genetic linkage map with 213 published SSR markers and two InDel markers. Quantitative trait locus (QTL) mapping identified 46 QTL for 12 agronomic traits, including 13 major effect QTL.

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MEK (mitogen-activated protein kinase) inhibitor is widely used for culturing pluripotent stem cells, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic stem cells (ESCs), implying a dual role of MEK/ERK (extracellular signal-regulated kinase) signaling in pluripotency maintenance. To better understand the mechanism of MEK/ERK in pluripotency maintenance, we performed quantitative phosphoproteomic analysis and identified 169 ERK substrates, which are enriched for proteins involved in stem cell population maintenance, embryonic development, and mitotic cell cycle. Next, we demonstrated that ERK phosphorylates a well-known pluripotency factor ESRRB on Serine 42 and 43.

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While sonodynamic therapy (SDT) has shown promise in treating triple-negative breast cancer (TNBC) due to its non-invasive nature, deep tissue penetration, and induction of immunogenic cell death (ICD), its efficacy remains limited by the complex immunosuppressive tumor microenvironment (TME). In this study, we developed tumor microenvironment-responsive nanoparticles (GdNPs) to enhance SDT effectiveness through epigenetic reprogramming of the TME by encapsulating the sonosensitizer chlorin e6 (Ce6) and the histone deacetylase 6 (HDAC6) inhibitor Ricolinostat (Ric) (GdNPs/Ce6-Ric). GdNPs/Ce6-Ric effectively accumulate at tumor sites via the enhanced permeability and retention (EPR) effect and release Ce6 and Ric in response to the acidic TME.

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Background And Purpose: Differentiating Parkinson's Disease (PD) from Atypical Parkinsonism Syndrome (APS), including Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), is challenging, and there is no gold standard. Integrating quantitative susceptibility mapping (QSM) and morphometry can help differentiate PD from APS and improve the internal diagnosis of APS.

Materials And Methods: In this retrospective study, we enrolled 55 patients with PD, 17 with MSA-parkinsonian type (MSA-P), 15 with MSA-cerebellar type (MSA-C), and 14 with PSP.

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Backgrounds: Adapter proteins (APs) complex is a class of heterotetrameric complexes comprising of 4-subunits with important regulatory functions in eukaryotic cell membrane vesicle trafficking. Foxtail millet (Setaria italica L.) is a significant C model plant for monocotyledon studies, and vesicle trafficking may plays a crucial role in various life activities related to growth and development.

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Pollen development and germination play a crucial role in the sexual reproduction of plants. This study analysis of transcriptional dynamics of foxtail millet pollen with other tissues and organs (ovule, glume, seedling and root) through RNA-sequencing revealed that a total of 940 genes were up-regulated in foxtail millet pollen. Based on this, we analyzed the genes involved in pollen tube growth of receptor kinases and small peptides, calcium signaling, small G proteins, vesicle transport, cytoskeleton, cell wall correlation, and transcription factors that are up-regulated in pollen.

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Article Synopsis
  • - Juvenile hormone (JH) is crucial for regulating insect development and reproduction, with levels fluctuating through different life stages, peaking during reproductive phases.
  • - The enzyme Jhamt controls JH production and its expression is influenced by two microRNAs (miR-276 and miR-182013-5p), which have opposing effects on Jhamt and JH levels.
  • - miR-276 acts as a "brake" by lowering Jhamt and JH levels, leading to early development, while miR-182013-5p acts as an "accelerator," increasing Jhamt and JH levels to extend development and boost reproduction.
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  • - We developed a new 2 µm nanosecond solid-state laser using a unique heterojunction saturable absorber, achieving stable pulses at a low pump power of 12.69 W.
  • - The laser emits pulses with a width of 818 ns and a maximum energy of 15.48 µJ, showing better performance compared to previous technologies.
  • - This innovative laser technology has potential applications in fields like atmospheric monitoring and lidar, offering significant advancements in mid-infrared pulsed laser systems.
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Designing and preparing highly sensitive and accurate fluorescent chemosensors for monitoring tetracycline antibiotics remains a challenge. Herein, a fluorescent chemosensor based on lanthanide metal-organic frameworks (Ln-MOFs) is proposed to realize high-precision monitoring by adjusting the ratio of lanthanide ions. Ln-MOFs with good aqueous stability were prepared by a solvothermal method using Eu, Tb and the ligand 4,4',4″-s-triazine-2,4,6-triyltribenzoic acid (HTATB) in DMF/NMP/HO.

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  • - Foxtail millet (Setaria italica) is an eco-friendly crop linked to food security and is useful for photosynthesis studies, but the impact of exogenous sucrose on its growth was previously unclear.
  • - Research involving physiological and molecular techniques revealed that sucrose treatment enhances photosynthesis in Jingu 21 seedlings by up-regulating several genes related to photosynthesis and carbohydrate metabolism.
  • - Key transcription factors like WRKYs and ERFs were identified as playing a significant role in this growth regulation, indicating that sucrose improves photosynthetic efficiency and could boost the yield of foxtail millet.
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In addition to preventing precocious larval metamorphosis, juvenile hormone (JH), synthesized in corpora allata (CA), is known to stimulate female reproduction of insects. JH titer is extremely low or absent during metamorphosis, but thereafter rapidly increases in the previtellogenic stage and rises to a peak in the vitellogenic phase. However, the mechanisms underlying the biosynthesis of high levels of JH in adults remain unclear.

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The study established split-root system (SRS) in foxtail millet, and identified the molecular regulatory mechanisms and metabolic pathways related to systemic nitrogen signaling based on this system and transcriptome analysis. The growth of crops is primarily constrained by the availability of nitrogen (N), an essential nutrient. Foxtail millet (Setaria italica L.

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  • Positron emission tomography/computed tomography (PET/CT) is a key imaging technique used to diagnose and differentiate Parkinson's disease (PD) from similar disorders in this study involving 220 patients with PD-like symptoms.
  • The study assessed the effectiveness of two tracers, C-2β-Carbomethoxy-3β-(4-fluorophenyl) tropane (C-CFT) and F-fluorodeoxyglucose (F-FDG), in distinguishing between PD, multiple system atrophy parkinsonian type (MSA-P), progressive supranuclear palsy (PSP), and vascular parkinsonism (VP).
  • Results indicated that PSP patients had the lowest C-C
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Article Synopsis
  • Multifunctional electrocatalysts are essential for improving electrochemical energy devices, with single-atom catalysts (SACs) showing significant potential.
  • Recent studies indicate that ultra-small transition-metal clusters, like Fe and Co, can enhance the catalytic performance of SACs through a process called axial coordination.
  • The research identifies IrN decorated with Fe as a standout trifunctional catalyst for oxygen and hydrogen reactions, with promising electrochemical properties, and provides insights into the mechanisms behind its enhanced performance.
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Seed germination represents a determinant for plants to enter ecosystems and is thus regarded as a key ecological and agronomic trait. It is tightly regulated by a variety of environmental cues to ensure that seeds germinate under favorable conditions. Here, we characterize BBX32, a B-box zinc-finger protein, as an imbibition-stimulated positive regulator of seed germination.

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Obesity and obesity-related metabolic disorders are global epidemics that occur when there is chronic energy intake exceeding energy expenditure. Growing evidence suggests that healthy dietary patterns not only decrease the risk of obesity but also influence the composition and function of the gut microbiota. Numerous studies manifest that the development of obesity is associated with gut microbiota.

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  • Amino acid permeases (AAPs) are vital for transporting amino acids in plants, but studies on foxtail millet are less advanced compared to crops like rice.
  • This research identified two AAP transcripts that are induced by nitric oxide, with one (SiAAP9) transporting more amino acids and having a significant impact on seed growth.
  • SiAAP9 also showed increased tolerance to glutamate and histidine, and its enhanced amino acid transport capabilities suggest it could improve the nutritional quality of foxtail millet through selective breeding.
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A novel colorimetric-fluorescent dual-mode chemosensor (JT5) based on rhodamine B has been produced for monitoring Sn in the DMSO/HO (4:1, v/v) medium. It has high sensitivity, a low detection limit, a short response time (1 s) and high stability, and can still be maintained after two weeks with the red dual fluorescence/ colorimetric response. Enhancement of red fluorescence (591 nm) and red colorimetric (567 nm) response of JT5 by Sn addition.

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Ecological factors related to climate extremes have a significant influence on the adaptability of organisms, especially for ectotherms such as reptiles that are sensitive to temperature change. Climate extremes can seriously affect the survival and internal physiology of lizards, sometimes even resulting in the loss of local populations or even complete extinction. Indeed, studies have shown that the expression levels of the nuclear genes and mitochondrial genomes of reptiles change under low-temperature stress.

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Diquat (DQ) is a typical bipyridine herbicide widely used to control weeds in fields and orchards. The severe toxicity of diquat poses a serious threat to the environment and human health. Metal-organic frameworks (MOFs) have received widespread attention due to their unique physical and chemical properties and applications in the detection of toxic and harmful substances.

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Reactive oxygen species (ROS) is a chemically reactive chemical substance containing oxygen and a natural by-product of normal oxygen metabolism. Excessive ROS affect the growth process of crops, which will lead to the decrease of yield. Nitrogen, as a critical nutrient element in plants and plays a vital role in plant growth and crop production.

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Brainbow is a genetic cell-labeling technique that allows random colorization of multiple cells and real-time visualization of cell fate within a tissue, providing valuable insights into understanding complex biological processes. However, fluorescent proteins (FPs) in Brainbow have distinct excitation spectra with peak difference greater than 35 nm, which requires sequential imaging under multiple excitations and thus leads to long acquisition times. In addition, they are not easily used together with other fluorophores due to severe spectral bleed-through.

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