Novel peptide inhibitor of matrix Metalloproteinases-1 from pufferfish skin collagen hydrolysates and its potential Photoprotective activity via the MAPK/AP-1 signaling pathway.

Takifugu bimaculatus, a pufferfish species farmed in Fujian Province, is known for its non-toxic flesh and collagen-rich skin. We identified a novel collagen-derived matrix metalloproteinase 1 (MMP-1) inhibitory peptide, from T. bimaculatus skin with potent anti-photoaging properties.

The coordination effect of organic ligands in Ce-MOF brings about atomically dispersed Fe in CeO for TAC detection in commercial samples.

Reducing the size of active species is a powerful means to improve the utilization rate of active metals and enhance the properties of bimetallic nanozymes. In this work, Fe was introduced into Ce-MOF through the coordination of Fe and organic ligands, and the coordination effect resulted in atomically dispersed Fe in the derived Fe/CeO nanozyme. Due to the atomically dispersed Fe embedded in the lattice of CeO, a large number of defect sites were generated, endowing the nanozyme with excellent peroxidase (POD)-like activity.

The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs.

Mechanisms controlling the movement of the cerebrospinal fluid (CSF) toward peripheral nerves are poorly characterized. We found that, in addition to the foramina Magendie and Luschka for CSF flow toward the subarachnoid space and glymphatic system, CSF outflow could also occur along periaxonal spaces (termed "PAS pathway") from the spinal cord to peripheral organs, such as the liver and pancreas. When interrogating the latter route, we found that serotonin, acting through 5-HT receptors expressed in ependymocytes that line the central canal, triggered Ca signals to induce polymerization of F-actin, a cytoskeletal protein, to reduce the volume of ependymal cells.

Antimicrobial resistance and clonal relationships of Salmonella enterica Serovar Gallinarum biovar pullorum strains isolated in China based on whole genome sequencing.

Background: Pullorum disease is a serious problem in many countries. Caused by Salmonella enterica serovar Gallinarum biovar Pullorum (S. Pullorum), it creates huge economic losses in the poultry industry.

Pathogenicity of Multidrug-Resistant Isolated from Ducks.

() is one of the most common serotypes in epidemiological surveys of poultry farms in recent years. It causes growth retardation, mortality, and significant economic losses. The extensive use of antibiotics has led to the emergence of multi-drug resistance (MDR) in Salmonella, which has become a significant global problem and long-term challenge.

Effects of on Production Performance and Bone Development of Laying Hens.

Probiotics are safe, inexpensive, and effective feed additives, and (CB) has been reported to regulate bone health in addition to having conventional probiotic effects. The bone health of laying hens is closely related to their production performance. Here, we investigated the effects of CB supplementation on the bone health and performance of laying hens.

Constructing Sequential Type II Heterojunction CQDs/BiS/TiNbO Photoanode with Superior Charge Transfer Capability Toward Stable Photoelectrochemical Water Splitting.

Efficient charge transfer and light-trapping units are pivotal prerequisites in the realm of Ti-based photoanode photoelectrochemical (PEC) water splitting. In this work, we successfully synthesized a ternary carbon quantum dots/BiS quantum dots/Nb-doped TiO nanotube arrays (CQDs/BiS/TiNbO) composite photoanode for PEC water splitting. CQDs/BiS/TiNbO composite photoanode exhibited a considerably elevated photocurrent density of 8.

Major depressive disorder: hypothesis, mechanism, prevention and treatment.

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear, and additional diagnostic and therapeutic strategies for MDD still are needed. The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD.

Characteristics, Whole-Genome Sequencing and Pathogenicity Analysis of from a White Feather Broiler Farm.

Avian colibacillosis, caused by avian (), has historically been one of the most prevalent infectious diseases in large-scale poultry production, causing growth delays and mortality in chickens, resulting in huge economic losses. In recent years, the widespread use of antibiotics has led to the emergence of multidrug resistance in as a significant global problem and long-term challenge. Resistant can be transmitted to humans through animal products or the environment, which presents significant public health concerns and food safety issues.

Whole-Genome Sequencing Analysis of Non-Typhoidal Isolated from Breeder Poultry Farm Sources in China, 2020-2021.

Non-typhoidal salmonellosis is a dangerous foodborne disease that causes enormous economic loss and threatens public health worldwide. The consumption of food, especially poultry or poultry products, contaminated with non-typhoidal (NTS) is the main cause of human salmonellosis. To date, no research has identified the molecular epidemiological characteristics of NTS strains isolated from breeder chicken farms in different provinces of China.

Research on land cover type classification method based on improved MaskFormer for remote sensing images.

High-resolution remote sensing images have the characteristics of wide imaging coverage, rich spectral information and unobstructed by terrain and features. All of them provide convenient conditions for people to study land cover types. However, most existing remote sensing image land cover datasets are only labeled with some remote sensing images of low elevation plain areas, which is highly different from the topography and landscape of highland mountainous areas.

A comprehensive review on oat milk: from oat nutrients and phytochemicals to its processing technologies, product features, and potential applications.

Plant-based milk alternatives have become increasingly desirable due to their sustainability and the increased consumer awareness of health. Among many varieties of emerging plant-based milk, the smooth texture and flavor of oat milk make it spread rapidly around the world. Furthermore, as a sustainable source of diet, oats can provide rich nutrients and phytochemicals.

Impact of COVID-19 restrictions on the concentration and source apportionment of atmospheric ammonia (NH) across India.

The wide spread of the coronavirus disease (COVID-19) has significantly influenced human activities around the world, providing a unique opportunity to investigate the response of air pollution to anthropogenic emission reduction. Compared with numerous studies on conventional air pollutants, atmospheric ammonia (NH) that has matched sources from both anthropogenic and natural emissions has been rarely investigated. Here we assess impacts of the COVID-19 lockdown on ambient NH variation across India, one of the most severe NH pollution region in the world.

A novel murine model of mania.

Neuropathological mechanisms of manic syndrome or manic episodes in bipolar disorder remain poorly characterised, as the research progress is severely limited by the paucity of appropriate animal models. Here we developed a novel mania mice model by combining a series of chronic unpredictable rhythm disturbances (CURD), which include disruption of circadian rhythm, sleep deprivation, exposure to cone light, with subsequent interference of followed spotlight, stroboscopic illumination, high-temperature stress, noise disturbance and foot shock. Multiple behavioural and cell biology tests comparing the CURD-model with healthy controls and depressed mice were deployed to validate the model.

Physical-Chemical and Sensory Quality of Oat Milk Produced Using Different Cultivars.

Oat milk, as an emerging plant-based milk substitute, has become popular in recent years. However, the stability and flavor of oat milk products are hindering their quality. The examination of the processing capacities of potential oat cultivars could help to improve product quality.

The influence of family function on online prosocial behaviors of high school students: A moderated chained mediation model.

The frequency of cyberbullying incidents is gradually increasing, and the seriousness of the consequences is gradually becoming more prominent. Previous studies have shown that cyberbullying bystander behaviors play an important role in reducing cyberbullying. This study aims to explore the mechanisms that high school students' family function, empathy, and social support levels how to affect their implementation of online prosocial behaviors when they act as cyberbullying bystanders.

Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice.

Posttraumatic stress disorder (PTSD) is very common after exposure to trauma, mental stress or violence. Because objective biological markers for PTSD are lacking, exactly diagnosing PTSD is a challenge for clinical psychologists. In-depth research on the pathogenesis of PTSD is a key for solving this problem.

Comparative Analysis between Isolated from Imported and Chinese Native Chicken Breeds.

is considered a significant threat to the global poultry industry and public health. In recent decades, antimicrobial resistance in has attracted increasing concern throughout the world. However, limited information is available on among different breeds of breeder chickens.

IFT20 Confers Paclitaxel Resistance by Triggering β-arrestin-1 to Modulate ASK1 Signaling in Breast Cancer.

Abstract: System paclitaxel-based chemotherapy is the first-line treatment regimen of defense against breast cancer, but inherent or acquired chemotherapy resistance remains a major obstacle in breast cancer therapy. Elucidating the molecular mechanism of chemoresistance is essential to improve the outcome of patients with breast cancer. Here, we demonstrate that intraflagellar transport 20 (IFT20) is positively associated with shorter relapse-free survival in patients with system paclitaxel-based chemotherapy.

Research Note: Effect of a live Salmonella Enteritidis vaccine against Salmonella Pullorum infection in breeder chickens.

Salmonella Pullorum is one of the most important avian pathogenic bacteria due to widespread outbreaks accompanied by high mortality. It has been demonstrated that the Salmonella Enteritidis live vaccine strain Sm24/Rif12/Ssq is able to induce cross-immunity protection against Salmonella Gallinarum and Salmonella Infantis, however, it is unknown whether this vaccine is effective against Salmonella Pullorum infection. In the present study, the Hubbard parent chickens were orally administrated this vaccine at 1-day-old, 40-day-old, and 131-day-old respectively, and challenged by Salmonella Pullorum at 157-day-old to evaluate the protective effect of the Salmonella Enteritidis live vaccine strain Sm24/Rif12/Ssq.

Oil Penetration of Batter-Breaded Fish Nuggets during Deep-Fat Frying: Effect of Frying Oils.

Four frying oils (rapeseed, soybean, rice bran, and palm oils) were employed either as received (fresh) or after preheating at 180 °C for 10 h, and measured for their fatty acid composition, viscosity, and dielectric constant. Batter-breaded fish nuggets (BBFNs) were fried at 180 °C (60 s), and the effect of the oils' quality on the oil penetration of fried BBFNs were investigated via the analysis of the absorption and the distribution of fat. Preheating increased the viscosity and dielectric constant of the oils.

[Urban thermal environment effects based on visual indices: A case study in Xuzhou City, China].

Urban thermal environments are closely related to habitats, citizens' health, and sustainable development. Based on green view index (GVI), we proposed two new visual indices, construction view index (CVI) and imperious surface view index (R&PVI). Mobile observation was used to obtain urban thermal environment data, images and coordinates synchronously in Xuzhou City in late summer, including urban area (U), scenic area (S), exterior of university campus (E), and university campus inside (CUMT).

Effects of Collagen Hydrolysate From Large Hybrid Sturgeon on Mitigating Ultraviolet B-Induced Photodamage.

Ultraviolet B (UVB) radiation leads to the excessive accumulation of reactive oxygen species (ROS), which subsequently promote inflammation, degradation of the extracellular matrix, and photoaging in skin. Thus antioxidant activity is particularly important when screening for active substances to prevent or repair photodamage. Marine fish-derived bioactive peptides have become a trend in cosmetics and functional food industries owing to their potential dermatological benefits.

Leptin Attenuates Fear Memory by Inhibiting Astrocytic NLRP3 Inflammasome in Post-traumatic Stress Disorder Model.

Accumulating evidence suggests that the activation of nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome contributes to the pathophysiology of post-traumatic stress disorder (PTSD). Astrocytes, the homeostatic cells of the central nervous system are intimately involved into pathophysiology of various mental disorders including PTSD. We demonstrated previously that leptin exerts neuroprotection and ameliorates chronic sleep deprivation-induced depressive-like behaviours.

Companion Animals as Potential Reservoirs of Antibiotic Resistant Diarrheagenic in Shandong, China.

Antibiotic resistance genes of () from companion animals were still poorly understood. Here, we investigated the extended-spectrum β-lactamases (ESBLs) resistance genes of from companion animals in Shandong, China. A total of 79 isolates (80.