Publications by authors named "Luling Yan"
RpIFN-λ1 alleviates the clinical symptoms of porcine epidemic diarrhea.
Int J Biol Macromol
December 2024
Article Synopsis
- Porcine epidemic diarrhea (PED), caused by PEDV, primarily impacts the small intestines of pigs, leading to significant health issues.
- Interferon-lambda (IFN-λ) shows strong antiviral effects at mucosal surfaces but is costly when extracted naturally; this study focuses on the recombinant version, rpIFN-λ1.
- The research demonstrated that rpIFN-λ1 effectively reduces PEDV replication, improves health outcomes for infected piglets, and enhances antiviral activity through the JAK-STAT signaling pathway, making it a promising and cost-effective treatment.
African swine fever virus (ASFV) has caused enormous economic losses since its first reported detection, and there is still no effective vaccines or drug treatment. During infection, viruses may employ various strategies, such as regulating the host endoplasmic reticulum stress/unfolded protein response or the formation of stress granules (SGs), to form an optimal environment for virus replication. However, how ASFV infection regulates host endoplasmic reticulum stress, eIF2α-regulated protein synthesis, and the formation of SGs remains unclear.
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