Long-Term Clinical Outcomes of the Transcatheter Aortic Valve System for Aortic Valve Stenosis.

Objective: To evaluate the clinical safety and efficacy of the self-expanding transcatheter aortic valve system in Chinese patients with severe aortic stenosis (AS) during follow-up.

Study Design: Observational study. Place and Duration of the Study: Department of Cardiology, Yulin First People's Hospital, The Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi, China, from April 2020 to September 2022.

Can proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors regress coronary atherosclerotic plaque? A systematic review and meta-analysis.

Objective: Whether inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the regression of coronary atherosclerotic plaque in statin-treated individuals remains unclear. This study examined whether PCSK9 inhibitors combined with statin therapy could increase atherosclerotic plaque regression compared with statin therapy alone.

Methods: PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), the database Clinical trials, and the Web of Science were searched to report the coronary atherosclerotic plaque of PCSK9 inhibitors using intravascular ultrasonography (IVUS) or optical coherence tomography (OCT) in statin patients.