Influence of Ukrain on the nuclear thyroid hormone receptors after short-term gamma-irradiation.

The ability of Ukrain, a semi-synthetic alkaloid thiophosphoric acid derivative (NSC-631579), to influence thyroid hormone levels in plasma and nuclear thyroid hormone receptors in female rat liver, as well as to modify the effects of short-term whole body gamma-irradiation on nuclear thyroid-hormone receptors in the liver was evaluated after intraperitoneal administration of the drug at 0.4 mg/kg body weight. Ukrain had no effect on the concentration of thyroid hormones in rat blood and increased the concentration of thyroid hormone receptors in the liver of intact rats during the first 2 months after administration.