[The radioprotective and antioxidant properties of solubilized alpha-tocopherol acetate].

A single intravenous administration of solubilized alpha-tocopherol acetate in a dose of 1 mg/kg to CBA x C57Bl x F1 male mice 3 and 24 hours before radiation was demonstrated to increase 30-day survival rates in the animals. Oily alpha-tocopherol acetate had the identical effects when the agent was intramuscularly given in a dose of 10 mg/kg. There was a rise in peripheral leukocyte counts 0.

[The content of immunoreactive calmodulin in the blood cells of irradiated animals].

The immunoreactive calmodulin content was shown to increase in the irradiated platelets of rats and cows. Total Ca content did not vary significantly in platelets of exposed animals although there was a tendency toward its increase. At the same time, total Ca content in lymphocytes of irradiated cows increased while the immunoreactive calmodulin level remained unchanged.

[Sandoglobulin immunocorrection in trauma].

Twenty one patients with the long-term compression syndrome (LCS) and 12 patients with burns treated with sandoglobulin in combination with antibacterial therapy were followed up. The control groups included 14 and 18 patients, respectively. All the patients had wound infections.

[Correction of immunologic disorders in patients with burns].

Addition of immunomodulating therapy with Thymalin, a thymus agent, to the multimodality therapy of burnt patients contributes to a rapid normalization of immunological parameters. The most marked immune response was observed 7-10 days after a therapy course initiated in the early periods of burn disease in patients with severely depressed T-system immunity and a high sensitivity to the drug. Inclusion of a donor blood leukomass transfusion course activates the cellular link of the immune system just after the treatment course, but fails to favour a stable normalization of thymus-dependent lymphocyte ratios.

[Effects of the open method of treatment on the status of the immune system in patients with deep thermal injuries].

The condition of the immune system in 56 patients with deep thermal damage was analysed according to the method of treatment; 30 patients were treated by the traditional bandage method, 26 patients--by the open method in bed with an air cushion of the "Klinitron" type. The study showed that the introduction of beds with an air cushion into clinical practice creates the most favorable conditions for the organism's adaptation in extreme functional stress and facilitates earlier normalization of the immune status; increase of the number of "active" T lymphocytes and theophylline-resistant T lymphocytes (helpers), marked reduction of the number of theophylline-sensitive T lymphocytes (suppressors), decrease of the level of circulating immune complexes, and normalization of the immunoglobulin-E content. The positive dynamics of changes of the condition of the immune system occurred during the earlier regeneration processes and when the patients felt better.

[Arterio-venous differences in the vascular and thrombocytic indices of the hemostasis system].

Arterio-venous difference in the functional activity of platelets and vascular wall was studied in Wistar rats. It was found that platelets, unlike leukocytes, were functionally more active in arterial than in venous blood. Athrombogenic activity of arteries was higher than that of veins.

[Vascular-platelet link in the hemostatic system of diabetics].

Activation of the vascular-platelet link of the hemostasis system: an increase in platelet ADP-induced aggregation, the appearance of platelet aggregates in the vascular bed, an increase in the patients' plasma of beta-thromboglobulin concentration, thrombocytic factor 4, a decrease in antiaggregation activity of the vascular wall and sensitifity of patients' platelets to antiaggregation action of acetylsalicylic acid, was found in diabetes mellitus patients. In the authors' opinion, the above changes play a role in disorders of the microcirculation of the organs and tissues and development of complications in these patients.

[Arteriovenous difference in antithrombin III activity and the antiaggregation properties of the vessel wall].

The paper is concerned with the data on the arteriovenous difference in antithrombin III activity and antiaggregation properties of the aortal and inferior vena cava walls in Wistar rats. A correlation between the changes identified and different thromboresistance of the arteries and veins is suggested.

[Effect of ionizing radiation on the functional state of the vascular-thrombocytic component of the hemostasis system].

The influence of ionizing radiation (gamma-rays 60Co) on aggregation activity of the vascular wall and functional (aggregation) platelet activity was studied in the course of the development of acute radiation sickness. The decrease in the aggregation properties of the vascular wall and high functional activity of platelets were inversely proportional, correlating with the periods of acute radiation sickness development and depending on the radiation dose. It is suggested that the changes detected may play a role in the pathogenesis of the development of the postirradiation thrombohemorrhagic syndrome.

[Functional damage of blood vessels and intravascular platelet aggregation in burns].

A study was made of the effect of burn injury on aggregation properties of the vascular wall and platelet aggregation capacity. Maximal accumulation of malonic dialdehyde during thrombin-induced aggregation, maximal rise of the spontaneous intravascular platelet aggregation index, and the most remarkable functional lesions of the vascular wall were observed in the early period (within the first hours), at the disease height (day 7), and during the recovery (day 30). Variation of the homestatic balance between the prostacycline- and thromboxane-generating systems of the blood vessels and platelets in the disease early period is linked with stress reaction and release of biologically active substances (adrenaline, cortisone) to the circulation, whereas at the disease height with marked inflammation and emergence in the blood of endotoxin and break down products of cell membrane phospholipids.

[Effect of 60Co gamma rays and fast neutrons on intravascular platelet aggregation and vessel wall prostacyclin activity].

The influence of gamma-rays 60Co and fast neutrons on intravascular platelet aggregation and prostacyclin activity of the vascular wall has been studied. It has been shown that 1-6 hours after irradiation of CBA mice, a great number of bone marrow platelets clump to form fibrin fibrils that often close completely the vascular lumen. Experiments with irradiated rats and guinea-pigs have demonstrated the reduction of prostacyclin-like activity in the abdominal aorta wall.

[Platelet dysfunction in diffuse toxic goiter and experimental thyrotoxicosis].

It was shown that in patients suffering from diffuse toxic goitre and in animals with experimental thyroxin toxicosis the platelet aggregation is decreased. Prostaglandin F2 alpha and cGMP restored platelet aggregating ability of patients and experimental animals while cAMP sharply lowered ADP-induced platelet aggregation in patients and animals with thyroxin toxicosis. Acetylsalicylic acid and indomethacin inhibited ADP-induced platelet aggregation approximately equally in patients and in healthy subjects.