Dual and Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells.

(1) Background: The c-Jun-NH2-terminal protein kinase (JNK) is a mitogen-activated protein kinase involved in regulating physiological processes in the central nervous system. However, the dual genetic deletion of and (upstream activators of JNK) in adult mice is not reported. The aim of this study was to induce the genetic deletion of in adult mice and analyze their effect in hippocampal neurogenesis.