Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in .

tRNA modifications help maintain tRNA structure and facilitate translation and stress response. Found in all three kingdoms of life, mA tRNA modification occurs in the T loop of many tRNAs, stabilizes tertiary tRNA structure, and impacts translation. MA in the T loop is reversible by three mammalian demethylase enzymes, which bypasses the need of turning over the tRNA molecule to adjust its mA levels in cells.

Internal mRNA 2'-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer.

In this issue, Li et al. report internal mRNA 2'-O-methyl (Nm) modification mapping by nanopore sequencing and the effect of Nm on mRNA stability and cancer cell progression.