Publications by authors named "Luke Newell"
Background & Aims: Despite increasing therapeutic options in the treatment of ulcerative colitis (UC), achieving disease remission remains a major clinical challenge. Nonresponse to therapy is common and clinicians have little guidance in selecting the optimal therapy for an individual patient. This study examined whether patient-derived materials could predict individual clinical responsiveness to the Janus kinase (JAK) inhibitor, tofacitinib, prior to treatment initiation.
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- Activity-driven changes in the neuronal surface glycoproteome involve a shift from immature to mature glycan forms due to increased neuronal activation.
- Researchers found that these glycan alterations are linked to the growth of Golgi satellites in dendrites, which operate as glycosylation stations during neuronal excitation.
- This process affects the dendritic surface's interaction with substances like lectins and alters the function of neurotransmitter receptors, indicating its potential role in synaptic plasticity, addiction, and neurological diseases.