Publications by authors named "Luke M Murphy"
Biguanides, including the world's most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favorable effects of metformin on longevity and on reducing the incidence and morbidity associated with aging-related diseases. Despite this promise, the full spectrum of molecular effectors responsible for these health benefits remains elusive.
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- Dietary mono-unsaturated fatty acids (MUFAs) are associated with increased lifespan in various species, with their mechanisms still being explored.
- Research shows that the number of lipid droplets and peroxisomes plays a key role in MUFA-induced longevity in the organism C. elegans.
- Findings indicate that MUFAs promote lipid droplet and peroxisome growth, which is crucial for longevity and suggests potential pathways for interventions to slow aging.
Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of the C. elegans riboflavin transporter 1 (rft-1) promotes metabolic health by reducing intracellular flavin concentrations.
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