Publications by authors named "Luke Isaac Jones"
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious lung disease marked by excessive collagen buildup, leading to respiratory failure, with no existing treatments to effectively reverse fibrosis despite some therapies that slow progression.*
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- The study used single-cell RNA sequencing and various models to investigate the role of O-linked N-Acetylglucosamine (O-GlcNAc) transferase (OGT) in regulating collagen production and fibrosis in IPF, finding it elevated in IPF patients and crucial in modulating Smad3 activation.*
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- Results suggest that inhibiting OGT can reduce collagen accumulation in IPF, making it a promising target for therapies aimed at both fibrosis resolution and other related diseases characterized by excessive extracellular
