Publications by authors named "Luke Bryant"
Objectives: To assess the prevalence of UK healthcare workers (HCWs) who reported symptoms of COVID-19 lasting for longer than 5 weeks and examine associated factors with experiencing long COVID in an ethnically diverse cohort.
Design: A cross-sectional study using data from the UK Research study into Ethnicity And COVID-19 Outcomes in HCWs cohort study.
Setting: Data were collected electronically between December 2020 and March 2021.
Article Synopsis
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Objectives: To assess how ethnicity, migration status and occupation are associated with healthcare workers (HCW) redeployment experiences during COVID-19 in a nationwide ethnically diverse sample.
Design: A cross-sectional analysis using data from the nationwide United Kingdom Research Study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH) cohort study.
Setting: Healthcare settings.
Article Synopsis
- A study was conducted to evaluate the effects of receiving the inactivated influenza vaccine (IIV) and SARS-CoV-2 vaccine at the same time compared to getting them separately among healthcare workers.
- Results showed that those who received both vaccines together had a lower rise in SARS-CoV-2 antibodies 1 month after vaccination, although this difference was not significant after 6 months.
- Overall, the concomitant vaccination did not seem to significantly affect the long-term immune response, suggesting that more research is needed to clarify these findings.
Background: Healthcare workers' (HCW) well-being has a direct effect on patient care. However, little is known about the prevalence and patterns of long-term medical conditions in HCWs, especially those from ethnic minorities. This study evaluated the burden of multiple long-term conditions (MLTCs), i.
View Article and Find Full Text PDFIntroduction: There are limited data on the outcomes of COVID-19 risk assessment in healthcare workers (HCWs) or the association of ethnicity, other sociodemographic and occupational factors with risk assessment outcomes.
Methods: We used questionnaire data from UK-REACH (UK Research study into Ethnicity And COVID-19 outcomes in Healthcare workers), an ethnically diverse, nationwide cohort of UK HCWs. We derived four binary outcomes: (1) offered a risk assessment; (2) completed a risk assessment; (3) working practices changed as a result of the risk assessment; (4) wanted changes to working practices after risk assessment but working practices did not change.
Background: Few studies have compared SARS-CoV-2 vaccine immunogenicity by ethnic group. We sought to establish whether cellular and humoral immune responses to SARS-CoV-2 vaccination differ according to ethnicity in UK Healthcare workers (HCWs).
Methods: In this cross-sectional analysis, we used baseline data from two immunological cohort studies conducted in HCWs in Leicester, UK.
Article Synopsis
- About 23.5% of healthcare workers (HCWs) in the UK show hesitancy towards receiving regular SARS-CoV-2 vaccinations, with certain groups being more hesitant, such as Black HCWs and those with previous COVID-19 infections.
- Factors influencing this hesitancy include trust in official vaccine information sources and prior influenza vaccination, where those who were vaccinated against influenza were significantly less likely to be hesitant.
- The study highlights the importance of addressing hesitancy in targeted groups to improve vaccine uptake and maintain immunity against SARS-CoV-2 among at-risk populations.
Article Synopsis
- * A nationwide study found that 35.2% of HCWs reported having aPPE at all times during the first lockdown, which improved to 83.9% by early 2021, highlighting a significant increase over time.
- * Factors influencing access to aPPE included age and work environment, with older HCWs and those in Intensive Care Units more likely to report consistent access, while Asian HCWs and those in non-medical roles were less likely to do so.
Background: Healthcare workers (HCWs), particularly those from ethnic minority groups, have been shown to be at disproportionately higher risk of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) compared to the general population. However, there is insufficient evidence on how demographic and occupational factors influence infection risk among ethnic minority HCWs.
Methods And Findings: We conducted a cross-sectional analysis using data from the baseline questionnaire of the United Kingdom Research study into Ethnicity and Coronavirus Disease 2019 (COVID-19) Outcomes in Healthcare workers (UK-REACH) cohort study, administered between December 2020 and March 2021.
Background: Several countries now have mandatory SARS-CoV-2 vaccination for healthcare workers (HCWs) or the general population. HCWs' views on this are largely unknown. Using data from the nationwide UK-REACH study we aimed to understand UK HCW's views on improving SARS-CoV-2 vaccination coverage, including mandatory vaccination.
View Article and Find Full Text PDFIntroduction: The COVID-19 pandemic has resulted in significant morbidity and mortality and devastated economies globally. Among groups at increased risk are healthcare workers (HCWs) and ethnic minority groups. Emerging evidence suggests that HCWs from ethnic minority groups are at increased risk of adverse COVID-19-related outcomes.
View Article and Find Full Text PDFA major challenge for breath research is the lack of standardization in sampling and analysis. To address this, a test that utilizes a standardized intervention and a defined study protocol has been proposed to explore disparities in breath research across different analytical platforms and to provide benchmark values for comparison. Specifically, theinvolves the targeted analysis in exhaled breath of volatile constituents of peppermint oil after ingestion of the encapsulated oil.
View Article and Find Full Text PDFBackground: In most countries, healthcare workers (HCWs) represent a priority group for vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) due to their elevated risk of COVID-19 and potential contribution to nosocomial SARS-CoV-2 transmission. Concerns have been raised that HCWs from ethnic minority groups are more likely to be vaccine hesitant (defined by the World Health Organisation as refusing or delaying a vaccination) than those of White ethnicity, but there are limited data on SARS-CoV-2 vaccine hesitancy and its predictors in UK HCWs.
Methods: Nationwide prospective cohort study and qualitative study in a multi-ethnic cohort of clinical and non-clinical UK HCWs.
Article Synopsis
- Captive breeding is essential for the survival of endangered primate species, with modern zoos playing a key role in their conservation and public education.
- A study was conducted to assess the impact of a scent enrichment program using essential oils on the well-being and behavior of several primate species at Dudley Zoo & Castle and Twycross Zoo in the UK.
- The results showed mixed outcomes, with some species reducing stress-related behaviors while others exhibited increased stress, indicating that the effectiveness of scent enrichment may vary based on individual species' social dynamics and olfactory preferences.
LabPipe: an extensible bioinformatics toolkit to manage experimental data and metadata.
BMC Bioinformatics
December 2020
Background: Data handling in clinical bioinformatics is often inadequate. No freely available tools provide straightforward approaches for consistent, flexible metadata collection and linkage of related experimental data generated locally by vendor software.
Results: To address this problem, we created LabPipe, a flexible toolkit which is driven through a local client that runs alongside vendor software and connects to a light-weight server.
Introduction: Investigating acute multifactorial undifferentiated breathlessness and understanding the driving inflammatory processes can be technically challenging in both adults and children. Being able to validate noninvasive methods such as breath analysis would be a huge clinical advance. The ReCIVA® device allows breath samples to be collected directly onto sorbent tubes at the bedside for analysis of exhaled volatile organic compounds (eVOCs).
View Article and Find Full Text PDFIntroduction: Patients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility in distinguishing patients with single organ pathologies but have poor discriminatory power in multifactorial presentations. Evaluation of volatile organic compounds (VOCs) in exhaled breath offers the potential to develop biomarkers of disease states that underpin acute cardiorespiratory breathlessness, owing to their proximity to the cardiorespiratory system.
View Article and Find Full Text PDFArticle Synopsis
- Precision medicine has led to advancements in molecular pathology, particularly in using exhaled breath as a non-invasive diagnostic tool.
- The study focuses on a new method for analyzing breath samples, utilizing advanced techniques like thermal desorption combined with comprehensive gas chromatography.
- Results showcase a well-optimized protocol for collecting and analyzing volatile organic compounds (VOCs), crucial for integrating breath analysis into large clinical studies.