Bariatric Surgery and the Long-Term Risk of Venous Thromboembolism: A Population-Based Cohort Study.

Purpose: Bariatric surgery is associated with a greater venous thromboembolism (VTE) risk in the weeks following surgery, but the long-term risk of VTE is incompletely characterized. We evaluated bariatric surgery in relation to long-term VTE risk.

Materials And Methods: This population-based retrospective matched cohort study within three United States-based integrated health care systems included adults with body mass index (BMI) ≥ 35 kg/m who underwent bariatric surgery between January 2005 and September 2015 (n = 30,171), matched to nonsurgical patients on site, age, sex, BMI, diabetes, insulin use, race/ethnicity, comorbidity score, and health care utilization (n = 218,961).

A One-Shot Lossless Algorithm for Cross-Cohort Learning in Mixed-Outcomes Analysis.

In cross-cohort studies, integrating diverse datasets, such as electronic health records (EHRs), is both essential and challenging due to cohort-specific variations, distributed data storage, and data privacy concerns. Traditional methods often require data pooling or complex data harmonization, which can reduce efficiency and limit the scope of cross-cohort learning. We introduce mixWAS, a one-shot, lossless algorithm that efficiently integrates distributed EHR datasets via summary statistics.

Quality of life after surgery for lower grade gliomas.

Background: Few large studies have investigated quality of life (QOL) for adults diagnosed with lower grade glioma (LGG).

Methods: QOL was assessed for 320 adults with LGG (World Health Organization grade 2/3) enrolled in the International Low Grade Glioma Registry by using the Medical Outcomes Study 36-Item Short Form health survey. Data on symptoms were also collected.

Estimating the change in soccer's home advantage during the Covid-19 pandemic using bivariate Poisson regression.

In wake of the Covid-19 pandemic, 2019-2020 soccer seasons across the world were postponed and eventually made up during the summer months of 2020. Researchers from a variety of disciplines jumped at the opportunity to compare the rescheduled games, played in front of empty stadia, to previous games, played in front of fans. To date, most of this post-Covid soccer research has used linear regression models, or versions thereof, to estimate potential changes to the home advantage.

Social media partnerships with patient organizations for neuro-oncology patient recruitment.

Background: In neuro-oncology, traditional methods of enrolling the large numbers of participants required for studies of disease etiology and treatment response are costly, labor intensive, and may not include patients in regions without tumor registries.

Methods: In the Yale Acoustic Neuroma (AN) Study and International Low-Grade Glioma (LGG) Registry, we partnered with several brain tumor patient organizations to develop social media enrollment campaigns and use web-based data collection resources at the Yale University School of Public Health to test alternative methods to enroll neuro-oncology patients for epidemiologic study.

Results: In the AN study, we enrolled 1024 patients over 2 years.

Quality of life after surgery for intracranial meningioma.

Background: To the authors' knowledge, limited data exist regarding long-term quality of life (QOL) for patients diagnosed with intracranial meningioma.

Methods: The data in the current study concerned 1722 meningioma cases diagnosed among residents of Connecticut, Massachusetts, California, Texas, and North Carolina from May 1, 2006 through March 14, 2013, and 1622 controls who were frequency matched to the cases by age, sex, and geography. These individuals were participants in a large, population-based, case-control study.