Publications by authors named "Luke A Potter"
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification, the addition of -linked β- acetylglucosamine (-GlcNAcylation), has been implicated in molecular mechanisms of both physiological and pathologic adaptations. The current study aimed to test the hypothesis that in cardiomyocytes, sustained protein -GlcNAcylation contributes to cardiac adaptations, and its progression to pathophysiology.
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- Spinal cord injury (SCI) causes rapid muscle loss, and while boldine, a CxHC-inhibiting compound, has shown potential in other conditions, it did not prevent muscle mass loss in mice with SCI.
- Boldine treatment did attenuate some SCI-induced metabolic and gene expression changes, particularly affecting amino acid levels and gene pathways related to ribosome biogenesis and protein degradation.
- This study is the first to analyze the metabolic and transcriptomic changes in skeletal muscle after SCI in mice, revealing significant alterations within the first week post-injury compared to later stages.
Article Synopsis
- Heart failure (HF) is a complex condition affecting many individuals worldwide, and only about 50% of patients benefit from standard treatments, highlighting the need to explore its molecular differences.
- A study investigated epigenetic factors in end-stage HF patients, analyzing DNA methylation patterns in cardiac biopsies from men receiving left ventricular assist devices (LVAD), revealing distinct methylation signatures based largely on race.
- The findings suggest that African American patients have a higher mortality rate post-LVAD compared to Caucasian patients, possibly linked to socioeconomic disparities, indicating a need for further research into how these factors impact heart failure outcomes.