A novel phospholipase A2 is a core component of the typhoid toxin genetic islet.

Salmonella Typhi, the cause of typhoid fever, is a bacterial pathogen of substantial global importance. Typhoid toxin is a secreted AB-type toxin that is a key S. Typhi virulence factor encoded within a 5-gene genetic islet.

Conserved patterns of sequence diversification provide insight into the evolution of two-component systems in .

Two-component regulatory systems (TCSs) are a major mechanism used by bacteria to sense and respond to their environments. Many of the same TCSs are used by biologically diverse organisms with different regulatory needs, suggesting that the functions of TCS must evolve. To explore this topic, we analysed the amino acid sequence divergence patterns of a large set of broadly conserved TCS across different branches of , a family of Gram-negative bacteria that includes biomedically important genera such as , , and others.

Identification of A Putative T6SS Immunity Islet in Salmonella Typhi.

Typhoid fever is a major global health problem and is the result of systemic infections caused by the human-adapted bacterial pathogen serovar Typhi (. Typhi). The pathology underlying .