Publications by authors named "Luke A Besse"
Article Synopsis
- The study investigates the relationship between the gut microbiome and cardiovascular disease (CVD), utilizing data from the long-term Framingham Heart Study to explore how individual microbes influence health.
- Using 16S rRNA gene sequencing on stool samples from over 1,400 participants, researchers analyzed the microbiome's diversity and composition in relation to clinical traits, lifestyle factors, and various health markers.
- Results indicate that lower microbial diversity is linked to higher CVD risk and body mass index; diet and exercise also affect microbial diversity, revealing both known and new associations between specific microbes and conditions like CVD and type 2 diabetes.
Purpose: Brain metastases can be radiographically cystic or solid. Cystic metastases are associated with a greater intracranial disease burden and poorer oncologic outcomes, but the impact of cystic versus solid appearance on local control after radiation remains unknown. We investigated whether cystic versus solid nature is predictive of local control after management with stereotactic or whole brain radiation (WBRT) and whether the radiation modality utilized is an effect modifier.
View Article and Find Full Text PDFBackground: Brain metastases commonly manifest in patients with cancer, with ∼20%-50% presenting with 1 intracranial lesion. Among patients with 1, small brain metastasis and controlled or absent extracranial disease, it remains unclear whether aggressive intracranial management using neurosurgical resection plus cavity stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) rather than SRS/SRT alone is beneficial. In patients with controlled or absent extracranial disease and 1 brain metastasis ≤2 cm in size, we evaluated the effect of surgery plus SRS/SRT compared with SRS/SRT on oncologic outcomes, including overall survival.
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