Neuroinflammation as a Link in Parkinson's and Alzheimer's Diseases: A Systematic Review and Meta-Analysis.

Neuroinflammation plays a critical role in Alzheimer's (AD) and Parkinson's diseases (PD) onset, pathophysiology, and progression. The aim of our meta-analysis was to review the available literature to assess the role of neuroinflammation in the pathogenesis of the two most common neurological diseases: Parkinson's disease and Alzheimer's disease. Two medical databases were searched: Web of Science and PubMed in the period from 2009-2023, where a total of 37 publications that met the inclusion criteria were selected for further evaluation.

The potential range of west Asian apple species Malus orientalis Uglitzk. under climate change.

The wild relatives of cultivated apples would be an ideal source of diversity for breeding new varieties, which could potentially grow in diverse habitats shaped by climate change. However, there is still a lack of knowledge about the potential distribution of these species. The aim of the presented work was the understand the impacts of climate change on the potential distribution and habitat fragmentation of Caucasian crab apple (Malus orientalis Uglitzk.

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis.

Introduction: Chronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also associated with sarcopenia and frailties. The objective of this study was to assess each cytokine: IL-6, TNF, and IL-1β separately in the elderly with comorbidities against controls without diseases according to the data published in the available literature.

Does excess body weight accelerate immune aging?

Background: Overweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic inflammation and thus enhancing immunosenescence. This study aimed to assess whether excess body mass affected disproportion in T lymphocytes. Therefore, the study was designed to explain whether excess body mass in older individuals affected the disproportion in numbers of T lymphocytes and whether anthropometric indices and immune risk profile expressed as CD4/CD8 ratio are diagnostically useful in the analysis of immunosenescence.

Evolutionary history of in the Caucasus driven by Middle and Late Pleistocene paleoenvironmental changes.

Due to global climate cooling and aridification since the Paleogene, members of the Neogene flora were extirpated from the Northern Hemisphere or were confined to a few refugial areas. For some species, the final reduction/extinction came in the Pleistocene, but some others have survived climatic transformations up to the present. This has occurred in , a species of high commercial value in Europe and a significant component of the Caucasian forests' biodiversity.

The Perspective of Arctic-Alpine Species in Southernmost Localities: The Example of in the Pyrenees and Carpathians.

High-mountain and arctic plants are considered especially sensitive to climate change because of their close adaptation to the cold environment. , a typical arctic-alpine species, reaches southernmost European localities in the Pyrenees and Carpathians. The aim of this study was the assessment and comparison of the current potential niche areas of in the Pyrenees and Carpathians and their possible reduction due to climate change, depending on the scenario.

Biodiversity protection against anthropogenic climate change: Conservation prioritization of in the South Caucasus based on genetic and ecological metrics.

The climate drives species distribution and genetic diversity; the latter defines the adaptability of populations and species. The ongoing climate crisis induces tree decline in many regions, compromising the mitigation potential of forests. Scientific-based strategies for prioritizing forest tree populations are critical to managing the impact of climate change.

The influence of climate and population density on Buxus hyrcana potential distribution and habitat connectivity.

Changes in environmental factors, human impact, and interactions between them accelerate the extinction of woody species. Therefore, conservation programs are needed to protect endangered taxa. However, the relationship between climate, habitat fragmentation, and anthropogenic activities and their consequences are still not well understood.

Assessment of metabolic syndrome predictors in relation to inflammation and visceral fat tissue in older adults.

The diagnosis of metabolic syndrome (MetS) focuses on the assessment of risk factors such as insulin resistance, dyslipidemia, central adiposity and elevated blood pressure. Evidence suggests that markers of systemic inflammation may also be included in the definition of MetS and play some role in its pathogenesis. The study was designed to evaluate low-grade inflammation status in older adults with MetS in relation to increased body fat tissue and an attempt was made to evaluate new predictors for MetS through the analysis of the ROC Curve.

The future of Viscum album L. in Europe will be shaped by temperature and host availability.

Viscum album L. is a plant of great importance due to its influence on the host trees and, by extension, entire ecosystems. The species is also significant to humans-on the one hand, because of its use in medicine, and on the other, because of the growing threat it poses to the stability of conifer stands.

Past climatic refugia and landscape resistance explain spatial genetic structure in Oriental beech in the South Caucasus.

Predicting species-level effects of climatic changes requires unraveling the factors affecting the spatial genetic composition. However, disentangling the relative contribution of historical and contemporary drivers is challenging. By applying landscape genetics and species distribution modeling, we investigated processes that shaped the neutral genetic structure of Oriental beech (), aiming to assess the potential risks involved due to possible future distribution changes in the species.

Environmental regionalization and endemic plant distribution in the Maghreb.

Clustering methods based on environmental variables are useful in the planning of conservation strategies for species and ecosystems. However, there is a lack of work on the regionalization of the vast space of North Africa and the distribution of plant species. The current lists of endemic plants are focused mostly on an occurrence at the country level and not on regions with different conditions.

Patterns of genetic diversity in North Africa: Moroccan-Algerian genetic split in Juniperus thurifera subsp. africana.

Juniperus thurifera is a key element of the forest communities in arid and semi-arid areas of the western Mediterranean. Previous genetic and morphological investigations suggested that Algerian populations are genetically more similar to European than to Moroccan populations and advocated their recognition at the variety rank. We aimed to investigate the spatial genetic structure in J.

Spatial genetic structure and diversity of natural populations of Aesculus hippocastanum L. in Greece.

Horse-chestnut (Aesculus hippocastanum L.) is an endemic and relict species from the Mediterranean biodiversity hotspot and a popular ornamental tree. Knowledge about the evolutionary history of this species remains scarce.