Metabolic memory - the implications for diabetic complications.

Many important biochemical mechanisms are activated in the presence of high levels of glucose, which occur in diabetes. Large randomised studies have established that early intensive glycaemic control reduces the risk of diabetic complications. This phenomenon has recently been dubbed 'metabolic memory'.

[Hypertension and prehypertension in children and adolescents with diabetes type 1].

Unlabelled: The aim of the study was to evaluate the prevalence of hypertension, prehypertension and circadian blood pressure rhythm disturbances with the analysis of chosen cardio-vascular risk factors in children and adolescents with diabetes type 1 (T1DM).

Material And Methods: The study group comprised 100 type 1 diabetic children (51 girls) with the mean age 15.4+/-2.

The perspectives of adjunctive drugs usage in the treatment of glucose metabolism disturbances in adolescent patients.

Tightening of the diabetes control criteria in the last few years induces searches for adjunctive drugs to reinforce the basic treatment typical for the specific type of the disease. These agents are meant to stimulate insulin secretion, increase insulin sensitivity or inhibit the antagonists of the hormone. Up till now that kind of studies included adults, mainly with type 2 diabetes.

Neuropathy and type 1 diabetes mellitus.

Diabetic neuropathy is the most common type of neuropathies. It affects patients with both type 1 and type 2 diabetes, but it progresses more rapidly and its manifestations are more severe in type 1 diabetes. Although there has been a significant progress in the understanding of the clinical aspects of these conditions, many questions remain unanswered.

Bacterial strains colonizing subcutaneous catheters of personal insulin pumps.

Continuous subcutaneous insulin infusion (CSII) is a commonly used, safe intensive insulin therapy method effective in maintaining normoglycaemia. The disadvantage of CSII are skin infections of the catheter injection site. The aim of the study was to gain insight on the colonization of subcutaneous insulin pump catheters by skin flora and to investigate the correlation between Staphylococcus aureus carrier state (presence in the nose), its presence on the skin and catheter.