Seven decades of clinical experience with Wilson's disease: Report from the national reference centre in Poland.

Background And Purpose: Wilson's disease (WD) is a rare autosomal recessive disorder causing excessive copper deposition and a spectrum of manifestations, particularly neurological and hepatic symptoms. We analysed the clinical characteristics of patients with WD admitted to the country's only reference centre, which provided long-term care to most adult patients in Poland over seven decades (pre-1959 to 2019).

Methods: Electronic prospective data collection began in the 2000s and, for prior years, medical records were analysed retrospectively.