Publications by authors named "Lukasz Eppa"
O:3 (YeO3) is considered to be associated with reactive arthritis (ReA), and its lipopolysaccharide (LPS) has been detected in synovial fluids from patients. Interestingly, YeO3 wild-type LPS was processed by host cells, resulting in truncated LPS molecules presenting the core region. Previously, we reported the immunogenicity but not adjuvanticity of YeO3 LPSs of wild (S) type, Ra, Rd, or Re chemotypes in mice.
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- A study involving 312 patients with multiple myeloma and lymphomas assessed the levels of ficolins (immune proteins) and their genetic polymorphisms before and after high-dose chemotherapy and stem cell transplantation.
- Findings showed that multiple myeloma patients had significantly lower levels of ficolin-1 and ficolin-2 compared to healthy controls, suggesting a link to the disease itself rather than post-transplant complications.
- Genetic variations in the ficolin genes were more frequently found in cancer patients, with some polymorphisms associated with a higher risk of infections post-chemotherapy, especially in lymphoma patients.
Article Synopsis
- - This study involved 312 patients with multiple myeloma and lymphomas undergoing high-dose chemotherapy and autologous stem cell transplantation, examining the role of certain gene polymorphisms and serum concentrations of immune-related proteins.
- - Findings indicated that multiple myeloma patients had a higher prevalence of MBL deficiency genotypes, but this was not linked to hospital infections or recovery of white blood cells, although it correlated with more severe infections during follow-up.
- - Interestingly, high levels of MBL were associated with prolonged fever and some infections post-chemotherapy, while a notable association between a gene mutation and lymphoma was identified, and overall, the influence of MBL on infections in these patients remains conflicting.
Deposition of mannose-binding lectin and ficolins and activation of the lectin pathway of complement on the surface of polyurethane tubing used for cardiopulmonary bypass.
J Biomed Mater Res B Appl Biomater
April 2018
The artificial surface used for cardiopulmonary bypass (CPB) is a crucial factor activating the complement system and thus contributing to the generation of a systemic inflammatory response. The activation of classical and alternative pathways on this artificial surface is well known. In contrast, lectin pathway (LP) activation has not been fully investigated, although noted during CPB in several studies.
View Article and Find Full Text PDFBoth complement activation and certain infections (including those with Yersinia sp.) may contribute to the pathogenesis of juvenile idiopathic arthritis (JIA). We investigated factors specific for the lectin pathway of complement: mannose-binding lectin (MBL), ficolins and MBL-associated serine protease-2 (MASP-2), in 144 patients and 98 controls.
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