Acute leukoencephalopathy associated with daratumumab treatment in POEMS syndrome: a case report.

Objectives: Daratumumab, a monoclonal antibody against CD38, is increasingly used in the treatment of multiple myeloma, other hematological malignancies and autoimmune diseases. Little is known about its CNS toxicity. We present a case of a patient with POEMS syndrome (syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) who developed an acute leukoencephalopathy shortly after initiation of therapy with daratumumab.

[A Slightly Different Gastroenteritis].

A Slightly Different Gastroenteritis Abstract. We report the case of a 81-year-old female presenting with gastroenteritic symptoms and laboratory findings of a hemolytic anemia, thrombocytopenia and acute renal failure with fatal outcome. A hemolytic-uremic syndrome caused by an infection with EHEC was diagnosed.

Relationship Between Rhinitis, Asthma, and Eczema and the Presence of Sensitization in Young Swiss Adults.

Background: Rhinitis is a very common disease with allergies being the most frequent causative factor. It can co-occur together with asthma and eczema in atopic as well as in nonatopic patients.

Objectives: To assess the prevalence of allergic sensitization within patient groups with rhinitis in consideration of the co-occurring disorders of asthma and eczema.

Atopy and related clinical symptoms among Swiss medical students from 2007 to 2015.

Background: Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. This study explored the prevalence of atopy and polysensitization in nine cohorts of Swiss medical students during the period of 2007-2015. Furthermore, the self-reported allergic symptoms, such as rhinoconjunctivitis, asthma and eczema, among students with and without atopy were assessed.