Desipramine effects on cocaine self-administration by rhesus monkeys.

The effects of desipramine treatment (0.56-10.0 mg/kg per day) on cocaine self-administration were compared to saline treatment in five rhesus monkeys.

Buprenorphine and naltrexone effects on cocaine self-administration by rhesus monkeys.

The effects of daily treatment with buprenorphine (0.237-0.70 mg/kg/day), naltrexone (0.

Ethanol-induced alterations in EEG alpha activity and apparent source of the auditory P300 evoked response potential.

The relationship among topographic brain electrical activity mapping, auditory-evoked response potentials (ERPs), plasma ethanol levels and subjective reports of intoxication was examined in 4 male volunteers. The source of the auditory P300 ERP (a measure of selective attention and memory encoding) was estimated using a recently developed computer program. The effect of ethanol on the P300 wave was studied using a standard oddball paradigm both with and without a concomitant divided attention task.

In vivo proton magnetic resonance spectroscopy of alcohol in human brain.

The covariance between blood and brain alcohol levels and subjective reports of mood were examined in 6 healthy adult men after consumption of 0.7 g/kg of beverage alcohol. There was significant (p less than 0.

Purification and characterization of a phospholipase A2 from human osteoarthritic synovial fluid.

Phospholipase A2 (PLA2) from human osteoarthritic synovial fluid was purified to homogeneity in three steps. The NH2-terminal amino acid sequence and biochemical characteristics of the enzyme were identical to the Peak A PLA2 activity of rheumatoid synovial fluid (1). The enzyme exhibited an apparent mass of 14,000, an absolute Ca+(+)-dependence, an alkaline pH optimum, and was inhibited by sodium deoxycholate (DOC), NaCl and 0.

Buprenorphine suppresses cocaine self-administration by rhesus monkeys.

Cocaine abuse has reached epidemic proportions in the United States, and the search for an effective pharmacotherapy continues. Because primates self-administer most of the drugs abused by humans, they can be used to predict the abuse liability of new drugs and for preclinical evaluation of new pharmacotherapies for drug abuse treatment. Daily administration of buprenorphine (an opioid mixed agonist-antagonist) significantly suppressed cocaine self-administration by rhesus monkeys for 30 consecutive days.

Topographic distribution of EEG alpha activity during ethanol-induced intoxication in women.

Topographic maps of brain electrical activity from scalp EEG electrodes were obtained from healthy adult female volunteers using a Brain Electrical Activity Mapping (BEAM) system. Each woman received both ethanol (0.7 g/kg, p.

A microanalysis of ethanol-induced disruption of body sway and psychomotor performance in women.

Measures of body sway, psychomotor performance and subjective reports of intoxication were obtained from 20 women after consuming either ethanol (0.56 g/kg) or placebo. Simple motor tasks were unaffected by the relatively low ethanol dose.

Differential tolerance development to buprenorphine-, diprenorphine-, and heroin-induced disruption of food-maintained responding in macaque monkeys.

Single daily subcutaneous injections of buprenorphine (1.0 mg/kg), diprenorphine (1.0 mg/kg), or heroin (1.

Alcohol-induced changes in body sway in women at risk for alcoholism: a pilot study.

Family history of alcoholism appears to influence acute alcohol responses in young men. We report pilot data from a study designed to expand these observations by measuring blood alcohol levels (BALs), subjective intoxication effects, body sway and cognitive-motor task performance in women. Six young women with (FHP) and six without (FHN) alcoholic first degree relatives provided informed consent and were given 0.

Progressive ratio performance maintained by buprenorphine, heroin and methadone in Macaque monkeys.

The relative reinforcing efficacy of buprenorphine (0.01-0.10 mg/kg/inj.

Blood ethanol levels, self-rated ethanol effects and cognitive-perceptual tasks.

Family history of alcoholism influences the acute effects of ethanol in young men. We expanded these findings by concomitantly measuring plasma ethanol levels (BALs), subjective intoxication effects, and task performance in young women. Healthy subjects with no familial alcoholism provided informed consent and received 0.

Electroencephalographic activity and plasma ACTH during ethanol-induced euphoria.

Covariance of brain electrical activity (EEG), plasma adrenocorticotrophic hormone (ACTH) and cortisol levels, and mood states were determined for healthy adult men during the first 2 hr after ingestion of ethanol or ethanol placebo under controlled double-blind conditions. Analysis of integrated plasma ACTH and cortisol levels at 5-min intervals, EEG power spectral analysis during consecutive 2-min epochs, and continuous assessment of mood states with a nonverbal instrumental device were carried out during the ascending phase of the blood ethanol curve. Ethanol induced rapid changes in brain electrical activity and plasma ACTH levels that were significantly correlated with subjective perception of changes in mood.

Acute alcohol effects on plasma estradiol levels in women.

Acute administration of alcohol (0.695 g/kg) to healthy adult women resulted in peak blood alcohol levels between 70 and 75 mg/dl within 50-60 min after initiation of drinking. Alcohol induced a significant increase (means = 18 pg/ml) in plasma estradiol levels (P less than 0.

Effect of gonadotropin-releasing hormone on prolactin levels in males unrelated to stress or behavioral changes.

Hormone levels, physiologic parameters, electroencephalographic (EEG) activity, and changes in subjective feelings recorded using a nonverbal instrumental device were assessed following the double-blind intravenous administration of 500 micrograms of gonadotropin-releasing hormone (GnRH) or placebo to five normal males. Within 30 minutes of GnRH administration, prolactin (PRL) levels had risen by 4.3 +/- 1.