Publications by authors named "Lukas S Schaffer"
Article Synopsis
- - The study investigates the genetic differences between Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), aiming to identify genetic factors that influence ASD independently of ADHD using advanced modeling techniques.
- - Results indicated that unique genetic aspects of ASD were positively correlated with cognitive outcomes and psychiatric traits, and specific gene expressions linked to ASD were identified, particularly in areas related to skin disorders.
- - Limitations included a narrow demographic focus on individuals of European ancestry and the challenge of understanding varied ASD traits due to reliance on general diagnoses.
Epidemiological literature has shown that there are extensive comorbidity patterns between psychiatric and physical illness. However, our understanding of the multivariate systems of relationships underlying these patterns is poorly understood. Using Genomic SEM and Genomic E-SEM, an extension for genomic exploratory factor analysis that we introduce and validate, we evaluate the extent to which latent genomic factors from eight domains, encompassing 76 physical outcomes across 1.
View Article and Find Full Text PDFImportance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in the phenotypic and genetic literature. However, a comprehensive model that investigates the association between a broad range of psychiatric disorders and immune-mediated disease in a multivariate framework is lacking.
Objective: This study aims to establish a factor structure based on the genetic correlations of immune-mediated diseases and investigate their genetic relationships with clusters of psychiatric disorders.
Article Synopsis
- Autism spectrum disorder (ASD) is a neurodevelopmental condition that often overlaps with ADHD, but researchers are exploring the distinct genetic risks that are specific to ASD.
- The study utilized advanced genetic modeling techniques to analyze the relationship between ASD and ADHD, breaking down their genetic signals and examining how they overlap with various other traits.
- Findings highlighted 83 unique genes linked to ASD, indicating that there are specific biological factors contributing to ASD that are independent of ADHD, underscoring the importance of tailored research in understanding these complex disorders.