The Real-World Impact of Long-Acting Injectable Cabotegravir-Rilpivirine on Weight and Renal Function.

Despite the continued advancement in the efficacy and convenience of antiretroviral therapy (ART), counseling patients about the metabolic side effects of medications remains an integral task for clinicians. This retrospective study examines changes in weight and renal function in patients receiving long-acting injectable cabotegravir-rilpivirine (LAI CAB/RPV) compared to oral regimens in a real-world setting. In this small set of patients, LAI CAB/RPV led to less weight gain compared to oral integrase inhibitor-based regimens.

Impacts of Road Salting on Water Quality in Fractured Crystalline Bedrock.

Many rural communities depend on bedrock wells as a primary water source, which raises the issue as to whether increasing amounts of salt application are affecting bedrock water quality and to what degree. Through wellbore profiling, this study investigated changes in specific conductance in two crystalline bedrock wells at the University of Connecticut in Storrs, CT, from 2003 to 2016, with particular emphasis on the impacts of increased salt application with a change in deicing practices at the university after 2009. Hourly specific conductance measurements were collected in 2014 to determine how water source may affect wellbore concentrations seasonally.

Permeable Asphalt: A New Tool to Reduce Road Salt Contamination of Groundwater in Urban Areas.

Chloride contamination of groundwater in urban areas due to deicing is a well-documented phenomenon in northern climates. The objective of this study was to evaluate the effects of permeable pavement on degraded urban groundwater. Although low impact development practices have been shown to improve stormwater quality, no infiltration practice has been found to prevent road salt chlorides from entering groundwater.