Publications by authors named "Lukas J-H Lee"
Article Synopsis
- Disrupted-in-Schizophrenia 1 (DISC1) is linked to various psychiatric disorders, and researchers created a mutant mouse model with a specific genetic deletion to study its effects on schizophrenia.
- * Heterozygous Disc1 mutant mice showed increased locomotor activity after amphetamine treatment compared to wild-type mice, indicating altered dopaminergic regulation in their brains.
- * Structural changes were observed in the striatum of mutant mice, including reduced complexity in neurons and decreased dendritic spine density, suggesting a potential connection between DISC1 gene variation and schizophrenia symptoms.
