Publications by authors named "Lukas Entenmann"
Article Synopsis
- The study investigates the cardiovascular risks associated with CAR T cell therapies in cancer patients, focusing on potential heart damage.
- It examines 137 patients from 2018-2022, assessing cardiac biomarkers and functions to predict severe cardiac events and overall mortality.
- Findings note that changes in a specific biomarker (hs-cTnT) shortly after treatment can predict all-cause mortality, while traditional risk factors and baseline measures did not effectively indicate cardiac issues.
Cancer patients are at risk of suffering from cardiovascular diseases (CVD). Nevertheless, the impact of cardiovascular comorbidity on all-cause mortality (ACM) in large clinical cohorts is not well investigated. In this retrospective cohort study, we collected data from 40,329 patients who were subjected to cardiac catherization from 01/2006 to 12/2017 at University Hospital Heidelberg.
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- Recent research indicates that osteocalcin (OCN) may play a role in various metabolic processes, including insulin sensitivity and steroid production.
- An analysis of plasma and urine samples from 931 participants using mass spectrometry revealed associations between OCN and various metabolites, with some links related to renal function and others remaining significant even after accounting for it.
- The study suggests that while OCN is connected to several metabolic pathways, its overall influence on whole-body metabolism appears to be limited, according to the identified associations.