Publications by authors named "Lukas Binting"
Article Synopsis
- Human cytomegalovirus (CMV) disrupts the antiviral response by depleting the STAT2 transcription factor, which is essential for signaling against viral infections.
- This depletion is mediated by the viral protein E27, which triggers the degradation of STAT2 using cellular mechanisms that involve ubiquitin ligase complexes.
- Structural analyses reveal how E27 mimics host proteins to effectively recruit and degrade STAT2, highlighting a conserved strategy for immune evasion in both rat and mouse models of CMV infection.
