Publications by authors named "Luka Krampert"
Inflamed and infected tissues can display increased local sodium (Na) levels, which can have various effects on immune cells. In macrophages, high salt (HS) leads to a Na/Ca-exchanger 1 (NCX1)-dependent increase in intracellular Na levels. This results in augmented osmoprotective signaling and enhanced proinflammatory activation, such as enhanced expression of type 2 nitric oxide synthase and antimicrobial function.
View Article and Find Full Text PDFArticle Synopsis
- FOXP3 regulatory T cells (Tregs) are crucial for preventing autoimmune responses, and their dysfunction can lead to autoimmunity with pro-inflammatory traits.
- High salt (HS) exposure alters Treg metabolism, mimicking features seen in autoimmune Tregs by disrupting mitochondrial function.
- The study suggests that short-term high salt intake can lead to long-lasting negative effects on Tregs, potentially increasing the risk of autoimmune conditions, but these effects may be reversible by targeting specific metabolic pathways.
Infection and inflammation can augment local Na abundance. These increases in local Na levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na on the antimicrobial activity of neutrophils remains elusive.
View Article and Find Full Text PDFAlthough matrix metalloproteinase 9 (MMP9) has been found associated with various psychiatric disorders and with threat memories in humans, its role in post-traumatic stress disorder (PTSD) and related animal models is understudied. Thus, we analyzed MMP9 mRNA expression kinetics during two different stress experiments, i.e.
View Article and Find Full Text PDFArticle Synopsis
- * The study utilized various advanced technologies to assess how HS influences immune cell activation, highlighting that HS leads to reduced mitochondrial respiration and altered immune responses.
- * Results showed that while HS improved bactericidal function in certain immune cells (M1-like macrophages), it impaired CD4 T cell migration in others (M2-like macrophages), indicating a complex relationship between salt intake and immune function.
Article Synopsis
- Inflammation and infection lead to increased sodium (Na+) levels in tissues, which enhances the activity of immune cells called macrophages (MΦs).
- The transcription factor NFAT5 is crucial for this process, as it boosts nitric oxide production and supports cell functions like autophagy.
- The study identifies NCX1, a sodium/calcium exchanger, as vital for sensing Na+ levels in MΦs, and its activity is important for effective inflammatory responses and antimicrobial functions under high salt conditions.