Publications by authors named "Luka Jedlovcnik"
Article Synopsis
- - Drp1, a protein involved in mitochondrial fission, contributes to the increase in pulmonary artery smooth muscle cells in pulmonary arterial hypertension (PAH), and researchers developed a new inhibitor called Drpitor1a to test its effectiveness.
- - Experiments showed that Drpitor1a successfully inhibited Drp1 activity, reduced cell proliferation and increased apoptosis in PAH cells, while not affecting normal cells or causing toxicity.
- - The findings suggest that Drpitor1a could be a viable treatment for PAH by targeting Drp1, with notable differences in effectiveness observed between male and female subjects.
Rationale: Dynamin-related protein 1 (Drp1), a large GTPase, mediates mitochondrial fission. Increased Drp1-mediated fission permits accelerated mitosis, contributing to hyperproliferation of pulmonary artery smooth muscle cells (PASMC), which characterizes pulmonary arterial hypertension (PAH). We developed a Drp1 inhibitor, Drpitor1a, and tested its ability to regress PAH.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan (China) in December 2019, COVID-19 rapidly spread globally, resulting in the COVID-19 pandemic. Carriers of the SARS-CoV-2 can experience symptoms ranging from mild to severe (or no symptoms whatsoever).
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