Publications by authors named "Lujun Gu"
Targeting tumor stemness is an innovative approach to cancer treatment. Zinc Finger Protein 207 (ZNF207) is a promising target for weakening the stemness of glioma cells. Here, a series of novel -(anthracen-9-ylmethyl) benzamide derivatives against ZNF207 were rationally designed and synthesized.
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- The study investigates how genetic variations in the PARP1 gene may influence DNA repair mechanisms, potentially affecting stroke risk and outcomes, particularly in a Chinese population.
- Researchers analyzed 1,000 individuals (500 stroke patients and 500 healthy controls) and found that elevated alcohol and smoking habits, alongside chronic conditions, were more prevalent in the stroke group.
- A specific polymorphism (rs8679) in the PARP1 gene was linked to a reduced risk of ischemic stroke and better initial stroke conditions, while its expression was suppressed by the interaction with the miR-124-5p molecule.
Objective: To determine the effect of PARP1 polymorphism on gene interactions.
Methods: A total of 500 patients and 500 healthy controls were enrolled.
Results: Analysis of clinical data showed that patients with stroke, diabetes, hypertension, and elevated serum triglyceride levels had higher levels of alcohol and smoking.
Single-nucleotide polymorphisms (SNPs) play an important role in our susceptibility to disease, the severity of illness and the way our body responds to treatment. This study evaluated the impact of three polymorphisms on the susceptibility and functional outcome of ischemic stroke (IS). Three hundred and eight patients and 300 healthy volunteers were enrolled.
View Article and Find Full Text PDFBackground/aims: Genetic polymorphisms of methylene tetrahydrofolate reductase (MTHFR) were associated with ischemic stroke risk. This study analyzed MTHFR polymorphisms at the 3'-untranslated region for association with risk and outcome of ischemic stroke in a Chinese Han population.
Methods: 500 patients and 600 healthy volunteers were enrolled for MTHFR rs868014 genotyping identified bioinformatically.