Modeling and Experiments of Droplet Evaporation with Micro or Nano Particles in Coffee Ring or Coffee Splat.

Experimental and numerical experiments were carried out to study the coffee rings or coffee splats formed by droplet evaporation with micro or nano polystyrene sphere particles ( = 10 μm or 100 nm). Particle image velocimetry (PIV) and a high-resolution camera were used in this experiment, along with a temperature-controlled heater and a data-acquisition computer. The results showed that a nano particle could form a homogeneous coffee splat, instead of the common coffee ring formed when using micro particles.

Visualizing Cytokeratin-14 Levels in Basal-Like Breast Cancer via ImmunoSPECT Imaging.

Cytokeratin-14 (CK14), also known as keratin 14, is mainly expressed in the basal layer of stratified squamous epithelium. It has a critical role in maintaining cell morphology and resisting external mechanical stress. High levels of CK14 have been found in multiple types of tumors, especially basal-like breast cancer (BLBC).

Radionuclide-Based Imaging of Breast Cancer: State of the Art.

Breast cancer is a malignant tumor that can affect women worldwide and endanger their health and wellbeing. Early detection of breast cancer can significantly improve the prognosis and survival rate of patients, but with traditional anatomical imagine methods, it is difficult to detect lesions before morphological changes occur. Radionuclide-based molecular imaging based on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) displays its advantages for detecting breast cancer from a functional perspective.

Synthesis and Preclinical Evaluation of a Ga-Radiolabeled Peptide Targeting Very Late Antigen-3 for PET Imaging of Pancreatic Cancer.

Pancreatic cancer is highly malignant and has a five-year survival rate of 5% due to an early lymph node, nerve, and vascular metastasis. Integrin αβ (also called very late antigen-3, VLA-3) is overexpressed in many tumors and plays a vital role in tumor formation, recurrence, and metastasis. In this study, we developed a Ga-radiolabeled peptide tracer targeting the α unit of VLA-3 and evaluated its potential application in positron emission computed tomography (PET) imaging of pancreatic cancer.

Red blood cell membrane-coated upconversion nanoparticles for pretargeted multimodality imaging of triple-negative breast cancer.

Upconversion nanoparticles (UCNPs) have been widely employed for tumor imaging using magnetic resonance imaging (MRI) and upconversion luminescence (UCL) imaging. The short blood clearance time and immunogenicity of UCNPs have limited their further application in vivo. We have designed UCNPs camouflaged with an exterior red blood cell (RBC) membrane coating (RBC-UCNPs) to solve these problems.

Ultra-sensitive Nanoprobe Modified with Tumor Cell Membrane for UCL/MRI/PET Multimodality Precise Imaging of Triple-Negative Breast Cancer.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer in which the estrogen receptor and progesterone receptor are not expressed, and human epidermal growth factor receptor 2 is not amplified or overexpressed either, which make the clinical diagnosis and treatment very challenging. Molecular imaging can provide an effective way to diagnose TNBC. Upconversion nanoparticles (UCNPs), are a promising new generation of molecular imaging probes.

C-Labeled Pictilisib (GDC-0941) as a Molecular Tracer Targeting Phosphatidylinositol 3-Kinase (PI3K) for Breast Cancer Imaging.

Pictilisib (GDC-0941) is an inhibitor of phosphatidylinositol 3-kinase (PI3K), part of a signaling cascade involved in breast cancer development. The purpose of this study was to evaluate the pharmacokinetics of pictilisib noninvasively by radiolabeling it with C and to assess the usability of the resulting [C]-pictilisib as a positron-emission tomography (PET) tracer to screen for pictilisib-sensitive tumors. In this study, pictilisib was radiolabeled with [C]-methyl iodide to obtain C-methylated pictilisib ([C]-pictilisib) using an automated synthesis module with a high radiolabeling yield.

Comparison of AlF- and Ga-labeled NOTA-PEG-LLP2A for PET imaging of very late antigen-4 in melanoma.

Malignant melanoma is an aggressive cancer with poor prognosis. Very late antigen-4 (VLA-4) is overexpressed in melanoma and many other tumors, making it an attractive target for developing molecular diagnostic and therapeutic agents. We compared AlF- and Ga-labeled LLP2A peptides for PET imaging of VLA-4 expression in melanoma.

Correction to: Targeted radiotherapy of pigmented melanoma with I-5-IPN.

AbstractIn the publication of this article [1], there is an error in affiliation 1. The revised affiliation has now been included in this correction.

Targeted radiotherapy of pigmented melanoma with I-5-IPN.

Purpose: There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (I-5-IPN) and evaluate its therapeutic ability and toxicity as a radioiodinated melanin-targeting therapeutic agent.

Synthesis and Preclinical Evaluation of F-PEG-FPN for the Detection of Metastatic Pigmented Melanoma.

Although F-5-fluoro-N-(2-[diethylamino]ethyl)picolinamide (F-5-FPN) is considered a promising radiopharmaceutical for PET imaging of melanoma, it accumulates at high concentrations in the liver. The aim in this research was to optimize the structure of F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. F-PEG-FPN was successfully prepared with a high radiolabeling yield (44.