Four-electron reduction of benzene by a samarium(II)-alkyl without the addition of external reducing agents.

Benzene reduction by molecular complexes remains an important synthetic challenge, requiring harsh reaction conditions involving group I metals. Reductions of benzene, to date, typically result in a loss of aromaticity, although the benzene tetra-anion, a 10π-electron system, has been calculated to be stable and aromatic. Due to the lack of sufficiently potent reductants, four-electron reduction of benzene usually requires the use of group I metals.

Scaling law for a buckled elastic filament in a shear flow.

We analyze the three-dimensional (3D) buckling of an elastic filament in a shear flow of a viscous fluid at low Reynolds number and high Péclet number. We apply the Euler-Bernoulli beam (elastica) theoretical model. We show the universal character of the full 3D spectral problem for a small perturbation of a thin filament from a straight position of arbitrary orientation.

From common to unreported: a real-world study of adverse events to duloxetine in the treatment of osteoarthritis.

Background: In a review of drug guidelines published by the International Association for the Study of Osteoarthritis, it is recommended to support the conditional use of duloxetine in patients with osteoarthritis. However, there is a lack of comprehensive research on the adverse events of duloxetine for the treatment of osteoarthritis populations.

Research Design And Methods: We used the reporting odds ratio (ROR) to determine the strength of the adverse event signal.

A novel cuproptosis-related lncRNA prognostic signature in thyroid cancer.

We aimed to investigate the value of cuproptosis-related lncRNA in screening out high-risk thyroid cancer patients. RNA sequencing data of thyroid cancer were obtained from The Cancer Genome Atlas. A cuproptosis-related lncRNA signature was constructed by using Cox regression.

Efficacy and safety of Jinhua Qinggan granules in the treatment of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.

Objective: To evaluate, using meta-analysis, the efficacy and safety profile of Jinhua Qinggan granules (JHQG) in the treatment of novel coronavirus pneumonia.

Methods: We screened multiple publication databases (PubMed, Embase, The Cochrane Library, Web of Science, CNKI, WanFang, and VIP), using parameters designed to identify articles detailing randomized controlled trials relating to the treatment of novel coronavirus pneumonia with JHQG. The inclusion period for each search was the point of database inception to November 2022.

Challenges and opportunities for chiral covalent organic frameworks.

As highly versatile crystalline porous materials, covalent organic frameworks (COFs) have emerged as an ideal platform for developing novel functional materials, attributed to their precise tunability of structure and functionality. Introducing chiral functional units into frameworks produces chiral COFs (CCOFs) with chiral superiorities through chirality conservation and conversion processes. This review summarises recent research progress in CCOFs, including synthetic methods, chiroptical characterisations, and their applications in asymmetric catalysis, chiral separation, and enantioselective recognition and sensing.

Traditional Chinese Medicine Based Acupoint Application for Asthma Treatment in Children: A Meta-Analysis and Systematic Review.

Objective: By conducting a systematic review of the efficacy of acupoint application on children with asthma.

Methods: We searched Chinese databases (CNKI, VIP, and Wanfang) and English databases (PubMed, Embase, and Cochrane Library) for studies from the establishment of the database to October 2021. The included literature studies were randomized control studies investigating the treatment of asthma in children by acupoint application.

Gut microbiota from nCAL patients promotes colon anastomotic healing by inducing collagen synthesis in epithelial cells.

Background And Aims: Colon anastomotic leak (CAL) is considered one of the most feared and serious postoperative complications in colorectal cancer (CRC) patients, with no effective prevention strategies to date. Based on previous studies, gut microbiota is associated with anastomotic healing, but its ability to effectively promote anastomotic healing remains largely unknown.

Methods: We performed a clinical study to analyze the gut microbiota profiling in CRC patients who developed CAL and those who did not (nCAL) using 16S-rRNA-based next-generation sequencing (NGS).

Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy.

Background: Thyroid hormone withdrawal (THW) in postoperative thyroid cancer patients who need always accompanied by complications (e.g., dyslipidemia and constipation).

Coupling Postsynthetic High-Temperature Oxidative Thermolysis and Thermal Rearrangements in Isoreticular Zinc MOFs.

Herein, we report coupling high temperature postsynthetic modifications (PSMs) in metal-organic frameworks (MOFs). Thermo-reactive propargyloxy-functionalized zinc IRMOFs (isoreticular metal-organic frameworks) prepared from 2-(prop-2-yn-1-yloxy)-[1,1'-biphenyl]-4,4'-dicarboxylic acid (HbpdcOCHCCH) were investigated for their high-temperature postsynthetic rearrangement (PSR) chemistry to heterocyclic chromenes and benzofurans and then coupled to solid-gas reactions with molecular oxygen. The selectivity for the initial molecular rearrangements was found to be inverted in the porous MOF environment compared to conventional melt reactions of the ester compound MebpdcOCHCCH and proceeded far more easily than the solid-state transformation from HbpdcOCHCCH, showing the potential of MOFs to give rise to different chemistry.

Activation of p38 mitogen-activated protein kinase pathway by lipopolysaccharide aggravates postoperative ileus in colorectal cancer patients.

Background And Aim: Patients undergoing abdominal surgery can develop postoperative ileus (POI). Inflammation of the intestinal muscularis following intestinal manipulation may be caused by displaced bacteria or lipopolysaccharide (LPS). The aim of this study was to investigate the relationship between gut microbiota, LPS, and POI in colorectal cancer (CRC) patients and explore underlying mechanisms of LPS-triggered POI.

Controlled n-Doping of Naphthalene-Diimide-Based 2D Polymers.

2D polymers (2DPs) are promising as structurally well-defined, permanently porous, organic semiconductors. However, 2DPs are nearly always isolated as closed shell organic species with limited charge carriers, which leads to low bulk conductivities. Here, the bulk conductivity of two naphthalene diimide (NDI)-containing 2DP semiconductors is enhanced by controllably n-doping the NDI units using cobaltocene (CoCp ).

Development and validation of survival nomograms in colorectal cancer patients with synchronous liver metastases underwent simultaneous surgical treatment of primary and metastatic lesions.

Colorectal cancer patients with synchronous liver metastases (CRSLM) can be treated by simultaneous surgery, that is the primary tumor and liver metastasis are removed at the same time. However, criteria for simultaneous surgery are underwent continuously modified and expanded. An appropriate selection of adequate candidates for simultaneous surgery is vital to get best benefits.

Prediction of Postoperative Ileus in Patients With Colorectal Cancer by Preoperative Gut Microbiota.

Background: Ileus and postoperative ileus (POI) are common complications of colorectal cancer (CRC). However, little is known about the gut microbiota associated with ileus.

Method: Differences in gut microbiota were evaluated by 16S rRNA gene sequencing.

Spin Crossover in Iron(III) Quinolylsalicylaldiminates: The Curious Case of [Fe(qsal-F)](Anion).

A family of iron(III) spin crossover complexes with different counteranions, [Fe(qsal-F)]A (qsal-F = 4-fluoro-2-[(8-quinolylimino)methyl]phenolate; A = PF , OTf , NO , ClO , BF , or NCS ) have been prepared. All compounds are isostructural and crystallize (triclinic 1̅ space group) with two independent iron(III) centers (Fe1 and Fe2) in the asymmetric unit. No solvent molecules are found in the crystal lattice, allowing us to directly probe the relative influence of anion variation on the spin crossover characteristics.

Chiral covalent organic frameworks: design, synthesis and property.

Covalent organic frameworks (COFs) are constructed using reticular chemistry with the building blocks being connected via covalent bonds and have emerged as a new series of porous materials for multitudinous applications. Most COFs reported to date are achiral, and only a small fraction of COFs with chiral nature are reported. This review covers the recent advances in the field of chiral COFs (CCOFs), including their design principles and synthetic strategies, structural studies, and potential applications in asymmetric catalysis, enantioselective separation, and chiral recognition.

Gut Microbiota-Based Algorithms in the Prediction of Metachronous Adenoma in Colorectal Cancer Patients Following Surgery.

Evaluating the risk of colorectal metachronous adenoma (MA), which is a precancerous lesion, is necessary for metachronous colorectal cancer (CRC) precaution among CRC patients who had underwent surgical removal of their primary tumor. Here, discovery cohort ( = 41) and validation cohort ( = 45) of CRC patients were prospectively enrolled in this study. Mucosal and fecal samples were used for gut microbiota analysis by sequencing the 16S rRNA genes.

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs.

Objectives: The aim of this study was to evaluate the effect of tectorigenin on treating allergic asthma model of guinea pigs and investigate the underlying mechanisms.

Methods: Allergic asthma model of guinea pigs was established by sensitizing with ovalbumin (OVA). Then OVA-sensitized guinea pigs were injected with 10 mg/kg tectorigenin, 25 mg/kg tectorigenin or dexamethasone to investigate the effect of tectorigenin.

Edge-exposed MoS nanospheres assembled with SnS nanosheet to boost NO gas sensing at room temperature.

SnS nanosheets (NSs) have become an ideal candidate for high performance gas sensors due to their unique sensing properties. However, the restacking and aggregation in the process of sensor manufacturing have great influence on the gas sensing performance. In this study, we synthesized a novel heterojunction of the flower-like porous SnS NSs with edge exposed MoS nanospheres via a facile hydrothermal method and sensitive response has achieved at room temperature (27℃).

Metal-Diamidobenzoquinone Frameworks via Post-Synthetic Linker Exchange.

Metal-organic frameworks with amidic linkers often exhibit exceptional physical properties, but, owing to their strong metal-nitrogen bonds, are exceedingly challenging to isolate through direct synthesis. Here, we report a route to access metal-diamidobenzoquinone frameworks from their dihydroxobenzoquinone counterparts via postsynthetic linker exchange. The parent compounds (MeNH)[ML] (M = Zn, Mn; HL = 2,5-dichloro-3,6-dihydroxo-1,4-benzoquinone) undergo linker exchange upon exposure to a solution of monodeprotonated 2,5-diamino-3,6-dibromo-1,4-benzoquinone or 2,5-diamino-3,6-dichloro-1,4-benzoquinone, proceeding through single-crystal-to-single-crystal reactions.

Reversible redox switching of magnetic order and electrical conductivity in a 2D manganese benzoquinoid framework.

Materials with switchable magnetic and electrical properties may enable future spintronic technologies, and thus hold the potential to revolutionize how information is processed and stored. While reversible switching of magnetic order or electrical conductivity has been independently realized in materials, the ability to simultaneously switch both properties in a single material presents a formidable challenge. Here, we report the 2D manganese benzoquinoid framework (MeN)[MnII2(L)] (HL = 2,5-dichloro-3,6-dihydroxo-1,4-benzoquinone), as synthesized post-synthetic counterion exchange.

Controllable synthesis of MoS@MoO nanonetworks for enhanced NO room temperature sensing in air.

MoS2 nanosheets (NSs) are a promising gas sensing material at room temperature (RT) due to their unique properties and structures. Unfortunately, the activity of pure MoS2 NSs is highly affected by the adsorption of atmospheric oxygen, which strongly influences the stability of MoS2 sensing devices and significantly hinders the practical applications of these sensors in air. Heterostructure formation may be an effective approach to modulate the intrinsic electronic properties of MoS2 NSs.

Intercalation of BiO/BiS nanoparticles into highly expanded MoS nanosheets for greatly enhanced gas sensing performance at room temperature.

Synthesizing a gas sensor based on heterostructured nanomaterials (NMs) via a controllable morphology by a facile hydrothermal method is an area of frontier research. In the present work, we designed a facile strategy to synthesize a controllable morphology and composition for three component heterojunctions (MoS-BiO-BiS) NMs using different hydrothermal reaction times. The BiS easily form as an intermediate phase due to the strong interaction of the BiO with MoS nanosheets (NSs).

Harnessing Structural Dynamics in a 2D Manganese-Benzoquinoid Framework To Dramatically Accelerate Metal Transport in Diffusion-Limited Metal Exchange Reactions.

Postsynthetic metal exchange represents a powerful synthetic method to generate metal-organic frameworks (MOFs) that are not accessible through direct synthesis, yet it is often hampered by slow reaction kinetics and incomplete exchange. While studies of metal exchange reactions have primarily focused on the transmetalation process, transport of exogenous metal ions into the framework structure represents a critical yet underexplored process. Here, we employ X-ray crystallography, electron microscopy, and energy dispersive X-ray spectroscopy to comprehensively examine the transport of Co and Zn ions during postsynthetic metal exchange reactions within the 2D manganese-benzoquinoid framework (EtN)[MnL] (HL = 3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone).

Therapeutic Effects of Kangzhi Syrup in a Guinea Pig Model of Ovalbumin-Induced Cough Variant Asthma.

Purpose: This study aimed to investigate the possible effects and underlying mechanisms of Kangzhi syrup on ovalbumin- (OVA-) induced cough variant asthma (CVA) in guinea pigs.

Methods: All 48 guinea pigs were randomly assigned to four experimental groups: normal, OVA model with or without Kangzhi syrup (OVA and OVA + KZ), and OVA with Dexamethasone (OVA + DM). After sensitizing the guinea pigs, a cough challenge was performed by the inhalation of capsaicin.