Publications by authors named "Luiza de O Macedo"
Article Synopsis
- * The hydrophobic nature of E2 makes it challenging to create effective delivery systems, but recent advancements in nano-based delivery systems, particularly lipid and polymeric nanoparticles, show promise in improving E2's stability and targeted delivery.
- * This review highlights the lack of extensive research on nano-delivery strategies for E2, emphasizing the need for more studies to develop and implement these therapies in clinical settings.
Despite the safety and convenience of oral administration, poorly water-soluble drugs compromise absorption and bioavailability. These drugs can exhibit low dissolution rates, variability between fed and fasted states, difficulty permeating the mucus layer, and P-glycoprotein efflux. Drug nanocrystals offer a promising strategy to address these challenges.
View Article and Find Full Text PDFDapsone (DAP)is a dual-function drug substance; however, its limited water solubility may impair its bioavailability. Drug nanocrystals are an alternative to overcome this limitation. Herein, a DAP nanosuspension was prepared using adesign space approach aiming to investigate the influence of raw material properties and process parameters on the critical quality attributes of the drugnanocrystals.
View Article and Find Full Text PDFAnti-inflammatory drugs have been prescribed extensively for a wide range of diseases. Combined with over-the-counter use, approximately 30 billion doses of non-steroidal inflammatory drugs (NSAIDs) are consumed annually in the USA. The global market of glucocorticoids (GCs) is forecast to reach US$ 8.
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