Publications by authors named "Luiza S Barbosa"
Antimicrobial resistance is an increasing worldwide public health burden that threatens to make existent antimicrobials obsolete. An important mechanism of antimicrobial resistance is the overexpression of efflux pumps, which reduce the intracellular concentration of antimicrobials. TolC is the outer membrane protein of an efflux pump that has gained attention as a therapeutic target.
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- * Gram-negative bacteria use efflux pumps to expel drugs, leading to multidrug resistance, making these pumps potential targets for new therapies.
- * This review discusses the potential of outer membrane proteins (OMPs) from efflux pumps as vaccine candidates against drug-resistant Gram-negative bacteria, while considering their diversity and impact on gut microbiota.