The use of medical remains unregulated in several countries due to the scarcity of clinical studies with high scientific evidence that establish safety and efficacy of products. This study aimed to comprehensively analyze how knowledge has been created in this field, as well as perform a bibliographic mapping to identify knowledge gaps, and investigate key authors and journals that have significantly contributed to advancing our understanding of . The study protocol was registered in the International Prospective Register of Systematic Review (CRD42020223084).
View Article and Find Full Text PDFEvidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions.
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