Publications by authors named "Luiza Cherobini Pereira"
Background: ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. Similarly, the expression and activity of CD73, an ectonucleotidase implicated in adenosine generation, is an important marker of tumor malignancy. Growing evidence suggests that EMT and the adenosinergic pathway are intricately linked and play a pivotal role in cancer development.
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- Metabolic adaptations play a key role in cancer development and treatment response, yet the role of mitochondrial dynamics in glioma cells' reaction to temozolomide (TMZ) is not well understood.
- Glioma cells show an increase in mitochondrial mass and produce abnormal mitochondria when exposed to TMZ.
- Asymmetric mitosis at the single-cell level leads to varied mitochondrial levels, impacting cell fitness during both treatment and control conditions, highlighting the importance of mitochondrial levels for glioma cells' health in the presence of TMZ.
Cancer cells have heterogeneous fitness, and this heterogeneity stems from genetic and epigenetic sources. Here, we sought to assess the contribution of asymmetric mitosis (AM) and time on the variability of fitness in sister cells. Around one quarter of sisters had differences in fitness, assessed as the intermitotic time (IMT), from 330 to 510 min.
View Article and Find Full Text PDFMesenchymal stromal cells (MSCs) are frequently recruited to tumor sites to play a part in the tumor microenvironment (TME). However, their real impact on cancer cell behavior remains obscure. Here we investigated the effects of human adipose-derived stromal cell (hADSC) secretome in autophagy of glioblastoma (GBM), as a way to better comprehend how hADSCs influence the TME.
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