Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues.

Background: Recent data suggest that up to 21% of positive circumferential margins (PCM) and 47% of extraprostatic extension (EPE) samples may be missed when partial embedding methods are employed. Kim and colleagues (2009) suggested that total inclusion of the periphery (3mm rim) of the prostate prevented the failure to detect PCM and EPE.

Design: Radical prostatectomy specimen (n=148) slides were reviewed after adoption of a protocol that included a ∼3 mm rim of peripheral tissues.

[Importance of the Teratogen Information Service in Bahia, Brazil, for prevention of congenital malformations: an initial four-year review].

Teratogenic agents are defined as physical, chemical, or biological agents or nutrient deficiencies that lead to fetal structural or functional alterations. Information on the effects of exposure to teratogens during pregnancy is of the utmost importance. In order to achieve this goal, in 2001, the Bahia State Teratogen Information Service was created in the Medical Genetics Department at the University Hospital of the Federal University in Bahia.