[Anti-inflammatory effect of high-density lipoprotein on the cardiovascular system of hyperlipidemic mice].

Introduction: LDLr-/- mice are spontaneously hyperlipidemic and resistant to the development of neointimal lesions.

Objectives: This study aimed to determine the factor that prevents the inflammatory process and neointimal lesions and insulin resistance in LDLr-/- mice.

Methods: Three groups of 3-month-old male mice were used: wild-type mice (WT group); LDLr-/- mice fed a standard diet (S group); and LDLr-/- mice fed a high-fat diet (HF group).