A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury.

Pediatric neurological injury and disease is a critical public health issue due to increasing rates of survival from primary injuries (e.g., cardiac arrest, traumatic brain injury) and a lack of monitoring technologies and therapeutics for treatment of secondary neurological injury.

Characterization and analysis of the bioactivity of the Piper rivinoides Kunth essential oil and its components myristicin and elemicin, against opportunistic fungal pathogens.

Candidiasis is an infectious disease caused by some fungi of the genus Candida. In Brazil, the incidence rate is higher than in European countries and the United States, and health problems occur mainly due to the virulence factors of the fungi, which have made treatment with commercial drugs difficult. Considering the context, plants rich in phenolic compounds, such as those of the genus Piper, have been studied due to their antimicrobial properties.

Acute metformin intake on exercise performance in healthy participants during functional fitness training.

Background: The study aimed to assess whether prior intake of metformin enhances performance in the FRAN workout, a popular Functional Fitness Training protocol.

Methods: Fourteen men (mean±SD: 24.2±3.

The role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases.

Introduction: The use of Hormone Dosage (HD) in Fine Needle Aspiration Biopsy (FNA) needle washout fluid, introduced in the 1990s, initially aimed at measuring Thyroglobulin (TG). Elevated TG concentration in an extrathyroidal cervical lesion suggests metastases of Well-Differentiated Thyroid Carcinomas (WDTC). Over the years, HD has evolved to incorporate Calcitonin (CT) and Parathormone (PTH), improving sensitivity and specificity in diverse clinical scenarios.

Quality of life and quality of sleep in health professionals working in critical areas.

Introduction: Emergency rooms and intensive care units in hospitals are physically and mentally stressful for health personnel and can negatively affect them.

Objectives: To evaluate and to compare the quality of life and quality of sleep of emergency room and intensive care unit personnel.

Methods: This is an analytical cross-sectional study conducted with 117 civil servants, including physicians, nurses, and licensed practical nurses.

Amplitude spectrum area is dependent on the electrocardiogram magnitude: evaluation of different normalization approaches.

Amplitude Spectrum Area (AMSA) of the electrocardiogram (ECG) waveform during ventricular fibrillation (VF) has shown promise as a predictor of defibrillation success during cardiopulmonary resuscitation (CPR). However, AMSA relies on the magnitude of the ECG waveform, raising concerns about reproducibility across different settings that may introduce magnitude bias. This study aimed to evaluate different AMSA normalization approaches and their impact on removing bias while preserving predictive value.

A fingerprint of source-specific health risk of PM-bound components over a coastal industrial city.

The influence of specific local land-use activities (continuously redistributing elements across environments) and environmental conditions (altering the chemical composition of airborne particulate matter) on the intrinsic health risk of PM exposure is sparsely reported. To fill this gap, we employed a novel integrated approach to address the influence of short-term changes in source-specific PM composition on the exposure-response risk, while controlling for weather conditions. We combine receptor-based source apportionment with conditional logistic regression in a space-time-stratified case-crossover design.

Willingness and skills among students from non-health academic fields in providing efficient basic life support.

Unlabelled: Education in basic life support is widely proposed to increase survival in out-of-hospital sudden cardiac arrest. The authors aimed to assess knowledge, skills, and attitudes, including willingness to help, regarding myocardial infarction and sudden cardiac arrest among university students of all fields of knowledge.

Methods: An Ethical Research Committee approved this cross-sectional study.

In vitro and in silico effect of meldrum's acid-derived compounds on Staphylococcus aureus strains as NorA efflux pump inhibitors.

The misuse of antibiotics has led to an alarming increase in bacterial strains resistant to these drugs. Efflux pumps, which expel antibiotics from bacterial cells, have emerged as one of the key mechanisms of bacterial resistance. In the quest to combat and mitigate bacterial resistance, researchers have turned their attention to efflux pump inhibitors as a potential solution.

Diagnosis of the risk of occupational disease among outsourced workers.

Introduction: The outsourcing of work activities has caused new and precarious working conditions, impacting the health and safety of workers, resulting in an increase in disease and accidents given the vulnerability established in the contemporary labor market.

Objectives: To identify the occurrence of risk of disease resulting from work, among outsourced workers.

Methods: Quantitative, observational, analytical and cross-sectional study, with application of the Inventário de Trabalho e Riscos de Adoecimento in 187 workers of a company that supplies and manages human resources for third parties, under contract with a Federal University, located in the state of Minas Gerais.

Tailoring 3D-printed sensor properties with reduced-graphene oxide: improved conductive filaments.

The development of a tailored filament is reported composed of reduced graphene oxide (rGO) and carbon black (CB) in a polylactic acid (PLA) matrix and its use in the production of electrochemical sensors. The electrodes containing rGO showed superior performance when compared with  those prepared in the absence of this material. Physicochemical and electrochemical characterizations of the electrodes showed the successful incorporation of both rGO and CB and an improved conductivity in the presence of rGO (lower resistance to charge transfer).

Tutton salt (NH)Zn(SO)(HO): thermostructural, spectroscopic, Hirshfeld surface, and DFT investigations.

Context: Ammonium Tutton salts have been widely studied in recent years due to their thermostructural properties, which make them promising compounds for application in thermochemical energy storage devices. In this work, a detailed experimental study of the Tutton salt with the formula (NH)Zn(SO)(HO) is carried out. Its structural, vibrational, and thermal properties are analyzed and discussed.

Use of Integral Forage Palm Flour as an Innovative Ingredient in New Fettuccine-Type Pasta: Thermomechanical and Technological Properties, and Sensory Acceptance.

Dehydrated integral forage palm cladode flour (FPF) presents a promising nutritional and functional approach to enriching fettuccine-type pasta. This study investigated the use of microwave-dehydrated FPF (at 810 W) as a partial wheat flour substitute (0, 5, 10, 15, and 20% /) in fresh and dry fettuccine-type pasta. The thermomechanical properties of flour blends and the technological and sensory attributes of the resulting pasta were evaluated.

Combination of Phytoactives in the Diet of Lactating Jersey Cows: Effects on Productive Efficiency, Milk Composition and Quality, Ruminal Environment, and Animal Health.

This study's objective was to evaluate whether adding a combination of phytoactive (microencapsulated essential oils, minerals, turmeric extract, tannin, prebiotic, and probiotic) to the feed of lactating Jersey cows positively affects the production, composition, and quality of milk, rumen environment, and animal health. Fourteen Jersey cows were divided into two groups (control and phytogenic) for an experiment with two lactation phases of 45 days each (early lactation and mid-lactation). During the experiment, milk production was higher at various times in cows that consumed phytoactive, and these animals had the best feed efficiency.

Factors associated with burnout in military police officers in a city in Paraná.

Objective: to analyze the association between burnout and sociodemographic, work factors, lifestyle habits and health conditions of military police officers in a municipality in the state of Paraná, Brazil.

Method: cross-sectional research with 131 military police officers. Data were analyzed using the Statistical Package for the Social Sciences software and the R program.

Fine-scale movement response of juvenile brown trout to hydropeaking.

Juvenile fish are known to be the most impacted during hydropeaking events due to stranding or uncontrolled drift resulting from changes to water depth and flow velocity. To shed light on their response to such hydraulic alterations, we coupled flume experiments with image-based fish tracking and quantified the fine-scale movement behavior of wild (n = 30) and hatchery-reared (n = 38) brown trout (Salmo trutta) parr. We exposed fish to two distinct hydropeaking treatments in a laterally inclined (14 %) flume section stocked with real cobbles to create refuge and heterogeneous hydraulic conditions.

Essential oils and capsaicin in the diet of Jersey cows at early lactation and their positive impact on anti-inflammatory, antioxidant and immunological responses.

The objective of this work was to determine whether the addition of phytogenic compounds based on essential oils (carvacrol, eugenol, cinnamaldehyde) and resinous pepper oil (capsaicin) to the diet of Jersey cows at the beginning of lactation affects anti-inflammatory, antioxidant and immunomodulatory responses, as well as whether there are effects of EO on blood metabolites, ruminal fermentation, digestibility and milk production and composition. Six primiparous cows (370.00 ± 17 kg body weight (BW); 13.

Highly sensitive voltammetric determination of hydrochlorothiazide using a glassy carbon electrode modified with Super P carbon black nanoparticles.

Hydrochlorothiazide is an extremely important diuretic that regulates body functions, which can prevent several diseases. However, the abuse of this diuretic is concerning since it does not require a medical prescription, particularly for aesthetic purposes such as weight loss, which can lead to various health problems, including ventricular arrhythmia. The present work aims to use a glassy carbon electrode modified with Super P carbon black (SPCB/GCE) to quantify hydrochlorothiazide through Linear Sweep Adsorptive Stripping Voltammetry (LSAdSV).

Analysis of the influence of occupational, sociodemographic and health factors on the demotivation of the intensivist.

Introduction: Understanding motivation, identifying motivational factors of health professionals, and recognizing how managers and leaders can successfully motivate healthcare professionals is a growing concern.

Objectives: To assess the occupational, sociodemographic, and health factors that influence the occurrence of demotivation in the intensive care unit professionals.

Methods: We performed a cross-sectional study with health professionals from nine intensive care units in João Pessoa, Paraíba state, Brazil.

Influence of extended working hours and physical recovery on absenteeism in the footwear industry from a system dynamics model.

. Work-related musculoskeletal disorders (WMSDs) are recurrent in the footwear industry, resulting in absenteeism. This study aimed to quantitatively analyze the influence of overtime work and physical recovery time on the occurrence of WMSD-related absenteeism using a system dynamics model.

Bioactive Compounds in Species with Potential for the Treatment of Chronic Venous Disease: A Review.

Chronic venous disease (CVD) significantly impacts global health, presenting a complex challenge in medical management. Despite its prevalence and the burden it places on healthcare systems, CVD remains underdiagnosed and undertreated. This review aims to provide a comprehensive analysis of the bioactive compounds in the genus, exploring their therapeutic potential in CVD treatment and addressing the gap in current treatment modalities.