Publications by authors named "Luiz Osorio Silveira Leiria"
Background: The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19 remain unclear.
Objectives: We aim to investigate the role of the Gasdermin-D (GSDMD) pathway on NETs release and the development of organ damage during COVID-19.
Article Synopsis
- Urological issues linked to sickle cell disease (SCD) include problems like frequent urination, bedwetting, and urinary infections, but the exact causes for these symptoms are not well understood.
- This study aimed to assess urinary function in a mouse model of SCD, particularly focusing on how their bladders and urinary systems perform.
- Findings revealed that SCD mice showed significantly reduced urine output and bladder contraction capabilities, alongside structural abnormalities in their bladders, indicating dysfunction in the urinary system related to SCD.
Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency.
Eur J Pharmacol
July 2015
Impairment of nitric oxide (NO) - cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have used a model of chronic NO synthesis inhibition to evaluate the functional alterations of prostate smooth muscle (PSM) machinery, and involvement of Rho-kinase pathway. Wistar rats were treated with the NO inhibitor N(ω)-nitro-l-arginine methyl ester (L-NAME, 20mg/kg/day; 4 weeks), after which contractile responses to phenylephrine (α1-adrenoceptor agonist; 1nM to 100µM), carbachol (muscarinic agonist; 1nM to 1mM) and α,β-methylene ATP (P2X receptor agonist; 1-10µM), as well as to electrical-field stimulation (EFS; 1-32Hz) were evaluated.
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