Publications by authors named "Luiz Filipe de A Alves"
Background: The class III histone deacetylase SIRT1 is overexpressed in many malignancies and has been implicated in inactivating proteins that are involved in tumor suppression and DNA damage repair. In the current study, we examined the expression of SIRT1 in normal epithelium (NE) compared with ocular surface squamous neoplasia (OSSN) to elucidate a possible role for SIRT1 in the development or progression of this malignancy.
Methods: We examined SIRT1 expression by immunohistochemistry in 47 cases of OSSN and 10 specimens of NE.