Publications by authors named "Luiz Fernando de C Rodrigues"
The effect of the ionic liquids (ILs) 1-methyl-3-tetradecylimidazolium chloride ([CMIM][Cl]), 1-dodecyl-3-methylimidazolium chloride ([CMIM][Cl]), and 1-decyl-methylimidazolium chloride ([CMIM][Cl]) on the structure of bovine serum albumin (BSA) was investigated by fluorescence spectroscopy, ultraviolet-visible (UV-vis) spectroscopy, small-angle X-ray scattering (SAXS), and molecular dynamics (MD) simulations. Concerning the fluorescence measurements, we observed a blue shift and a fluorescence quenching as the IL concentration increased in the solution. Such behavior was observed for all three studied imidazolium-based ILs, being larger as the number of methylene groups in the alkyl chain increased.
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- SGTs are dimeric co-chaperone proteins with distinct domains that play a role in protein quality control (PQC) by interacting with other proteins and aiding stress recovery.
- Research on AaSGT, a putative SGT from the Aedes aegypti mosquito, showed it can stabilize proteins and maintain stability at higher temperatures.
- Understanding the structure and function of AaSGT enhances our knowledge of PQC in Aedes aegypti, which could lead to strategies for controlling diseases transmitted by this mosquito.
Cellular proteostasis is maintained by a system consisting of molecular chaperones, heat shock proteins (Hsps) and proteins involved with degradation. Among the proteins that play important roles in the function of this system is Hsp90, which acts as a node of this network, interacting with at least 10% of the proteome. Hsp90 is ATP-dependent, participates in critical cell events and protein maturation and interacts with large numbers of co-chaperones.
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