Publications by authors named "Luiz Fernando Nunes"
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with low survival rates, primarily treated through surgery and radiation, as highlighted by the Brazilian Society of Surgical Oncology's guidelines on its management.
- - The consensus emphasizes the importance of comprehensive staging, including imaging techniques like PET or CT scans, and recommends that all potential MCC cases be evaluated by a multidisciplinary team, including discussions in tumor boards to prevent treatment delays.
- - For early-stage patients (clinical stage I or II), local excision and sentinel lymph node biopsy are advised, while those with positive lymph nodes should receive radiation therapy, and advanced cases should consider participation in clinical trials for treatment options.
Background: Acral melanoma is rare and associated with a worse prognosis compared to cutaneous melanoma in other locations. Despite this, few studies have focused on the prognosis of acral melanoma, particularly in patients with initial clinical stage. The aim of this study was to assess the impact of clinical and histopathological characteristics on the disease-free survival (DFS) of stage I-II patients.
View Article and Find Full Text PDFThe Protein Structure Prediction (PSP) problem comprises, among other issues, forecasting the three-dimensional native structure of proteins using only their primary structure information. Most computational studies in this area use synthetic data instead of real biological data. However, the closer to the real-world, the more the impact of results and their applicability.
View Article and Find Full Text PDFBackground: Sentinel lymph node biopsy (SLNB) is the most powerful predictor of relapse-free survival (RFS) and overall survival (OS). No studies have evaluated survival of acral melanoma (AM) undergoing SLNB in Brazil.
Objective: The objective of this study was to investigate the factors associated with the survival of patients with AM undergoing SLNB.
Background: Subungual melanoma (SM) is rare. The lesions are thick at the time of diagnosis. Few studies have evaluated SM in Brazil.
View Article and Find Full Text PDFMalignant degeneration of pilonidal cysts is rare. The most common histologic type is the squamous cell carcinoma, triggered by the chronic inflammatory process. The growth of the lesion is typically slow.
View Article and Find Full Text PDFObjective: To relate the clinical characteristics and evaluations of patients with epithelioid sarcomas.
Methods: Careful analysis of 25 epithelioid sarcoma cases registered in Instituto Nacional do Cancer between june 1987 and july 2005.
Results: Mean age at diagnosis was 33 years old, ranged from 10 to 70.