How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process?

Here we investigate metabolic changes, the antioxidant system and the accumulation of oxidative damage in muscles with different fiber types during the aging process in Wistar rats and try to map how sooner the changes occur. To do so, 30 male Wistar rats were submitted to behavioral evaluation to determine voluntary strength in the 11, 15, and 19 month old rats, measuring the energy metabolism, antioxidant system, oxidative damage and structure in the soleus and extensor digitorum longus muscles. We detected structural and metabolic changes in both muscles, especially in the EDL of 15 month old rats and in the soleus of 19 month old rats.

Correlation between levels of perceived stress and depressive symptoms in the functional disability of patients with fibromyalgia.

Objective: The aim of this study was to evaluate the factors that are most correlated with the levels of functional disability in patients with fibromyalgia.

Methods: This is a cross-sectional descriptive study in which 42 patients diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology reported their status using the following questionnaires: the Beck Depression Inventory, the Perceived Stress Scale 14, the Revised Fibromyalgia Impact Questionnaire, the Visual Analog Pain Scale, and the Health Assessment Questionnaire.

Results: Moderate to severe levels of depression (Beck Depression Inventory: 22.

Regulation of Redox Profile and Genomic Instability by Physical Exercise Contributes to Neuroprotection in Mice with Experimental Glioblastoma.

Glioblastoma (GBM) is an aggressive, common brain cancer known to disrupt redox biology, affecting behavior and DNA integrity. Past research remains inconclusive. To further understand this, an investigation was conducted on physical training's effects on behavior, redox balance, and genomic stability in GBMA models.

An Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to the MSG-Induced Obesity Model.

The model of obesity induced by monosodium glutamate cytotoxicity on the hypothalamic nuclei is widely used in the literature. However, MSG promotes persistent muscle changes and there is a significant lack of studies that seek to elucidate the mechanisms by which damage refractory to reversal is established. This study aimed to investigate the early and chronic effects of MSG induction of obesity upon systemic and muscular parameters of Wistar rats.

A prospective, longitudinal, case-control study to evaluate the neurodevelopment of children from birth to adolescence exposed to COVID-19 in utero.

Background: The Coronavirus disease (COVID-19) pandemic has created unprecedented acute global health challenges. However, it also presents a set of unquantified and poorly understood risks in the medium to long term, specifically, risks to children whose mothers were infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy. Infections during pregnancy can increase the risk of atypical neurodevelopment in the offspring, but the long-term neurodevelopmental impact of in utero COVID-19 exposure is unknown.

Physical Training Protects Against Brain Toxicity in Mice Exposed to an Experimental Model of Glioblastoma.

Glioma 261 (Gl261) cell-mediated neurotoxicity has been reported in previous studies examining glioblastoma (GBM), and the effects of physical exercise (PE) on this neurotoxicity have been poorly investigated. This study aimed to evaluate the effects of a PE program in animals with experimental GBM. Male C57BL/6J mice were randomized into sham or GBM groups and subjected to a PE program for four weeks.

Improving the quality of organic compost of sewage sludge using grass cultivation followed by composting.

Composting is one of the main processes of stabilization of sewage sludge and its association with cultivation in this residue has a great potential to produce stabilized organic fertilizer and, or substrate for plant development. The aim of this work was to evaluate the physical, chemical, and microbial attributes of sewage sludge (SS) aerated and cultivated with Pennisetum purpureum or Urochloa brizantha and, later, composted. The study was installed in a 2x2+2 factorial scheme, with four replications.

Biochar-cadmium retention and its effects after aging with Hydrogen Peroxide (HO).

Cadmium (Cd) is a highly toxic heavy metal that can become available to the environment from a variety of sources. The thermal transformation of organic residues into biochar can be a sustainable way to reduce cadmium environmental availability and, at the same time, a waste management solution. We studied sixteen biochars in two versions: unaged and aged with hydrogen peroxide (HO), regarding their Cd retention capacity.

Responses of marine zooplankton indicators after five years of a dam rupture in the Doce River, Southeastern Brazil.

Since November of 2015, when ore tailings from a dam rupture reached the Atlantic Ocean, researchers are trying to assess the degree of impact across the Doce River and adjacent coastal area. This study aims to use the zooplankton dynamics as a tool to evaluate the environmental impact in the coastal region, five years after the rupture, during periods of low and high river flow. Doce River flow varied from 49 to 5179 m/s and structured the zooplankton community between periods of low and high river flow, but salinity and chlorophyll-a had stronger correlation with depth (r = 0.

An integrated study of the plankton community after four years of Fundão dam disaster.

Mining activities can affect the environment either by the tailings releasing or dams failures. The impact of the tailings can last decades and cause chronic effects due to their toxicity. The Fundão dam collapse, a relevant environmental disaster, occurred in November 2015 in Southeastern Brazil.

How to minimize bleeding in laparoscopic myomectomy.

Purpose Of Review: Laparoscopic myomectomy is a common surgical procedure for symptomatic myomas. However, bleeding control during surgery may pose a challenge. Therefore, the aim of this study was to review recent evidence regarding interventions to control bleeding during laparoscopic myomectomy.

Effect of watercress extract supplementation on lipid profile and oxidative stress markers in overweight people with physical disability: A randomized, double-blind, and placebo-controlled trial.

Studies have demonstrated that diet rich in cruciferous vegetables of the Brassicaceae family can reduce the risk of cardiovascular diseases and oxidative stress levels. Nasturtium officinale (Brassicaceae), commonly known as watercress is a perennial dicotyledonous plant usually found close to water. Although previous investigations have demonstrated the beneficial effects of watercress on hypercholesterolemia in animal studies, until now no such studies have been conducted with humans, up to this time.

Obesity-like metabolic effects of high-carbohydrate or high-fat diets consumption in metabolic and renal functions.

Present study investigated which diet, high-carbohydrate (HCD) or high-fat (HFD), most effectively induces classical characteristics of obesity in mice. Mice were fed commercial chow (control), an HCD, or an HFD for 12weeks. HFD and HCD increased body weight, fat mass, and glycaemia, whereas the HFD augmented insulinemia.

Structural and elemental analysis of biochars in the search of a synthetic path to mimetize anthropic Amazon soils.

In this work, chemical and structural properties of various biochars were analyzed and compared with those from a highly stable anthropic soil, Terra Preta de Índio (TPI). TPI is believed to be responsible for the fertility of Amazonian soils and their stability; therefore, the production of a synthetic TPI would be of great interest for agricultural applications. Biochar produced from different raw biomasses were comprehensively characterized and, based on the obtained results, a preliminary study was performed testing three different routes of chemical activation using nitric acid, phosphoric acid, and potassium hydroxide as activating agents.

Bilateral ureteral endometriosis-an indolent, aggressive, and dangerous condition.

Objective: To describe an unusual bilateral ureteral reimplantation due to endometriosis and to provide a flowchart of conservative decision making.

Design: Video description of a case, demonstrating a step-by-step explanation of the decision planning and description of the surgical steps in a female patient with bilateral ureteral endometriosis who had previously undergone operation for bowel endometriosis, and who presented with extensive disease in the posterior compartment with no symptoms besides bilateral renal function disruption. The study was reviewed and approved by the Hospital Beneficência Portuguesa de São Paulo Institutional Review Board.

Fish oil supplementation enhances colon recovery after experimental colitis.

Introduction: Fish oil (FO) has an anti-inflammatory and pro-resolution activity and it has been used to restore physiological disturbances on inflammatory conditions. Here, we investigate whether FO supplementation could, acutely, prevent or restore inflammatory damages on experimental colitis.

Methods: Wistar rats orally received 2 g.

Rhizosphere microbiological processes and eucalypt nutrition: Synthesis and conceptualization.

In this review, we present the state of art regarding rhizosphere effects on eucalypt plantations. It provides a greater understanding of carbon (C) and nitrogen (N) turnover in forest soils. P organic hydrolysis, soil mineral solubilization, indoleacetic acid, gibberellin, resistance factors, and production of siderophores by rhizosphere microbial populations help to explain the tolerance of Eucalyptus plants to biotic and abiotic stresses and the apparent steady-state condition of C and N soil stocks in many planted forests.

Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract of Nasturtium officinale: A randomized, double-blind, and placebo-controlled trial.

It is well established that plants from the Brassicaceae family, particularly watercress, have been associated to reduce oxidative DNA damage. Nasturtium officinale R. Br (watercress) contains glucosinolates, with anti-inflammatory action and protective effect on human health against oxidative stress.

Marine zooplankton dynamics after a major mining dam rupture in the Doce River, southeastern Brazil: Rapid response to a changing environment.

Zooplankton were sampled five days after the tailings from the Samarco dam rupture reached the ocean in the coastal region at the mouth of the Doce River. This was one of the largest environmental disasters in Brazilian history, and the impacts on the marine biota are not yet fully understood. This study aimed to evaluate the zooplankton community short term responses to the metal enrichment after the tailings reached the coastal region in different scenarios.

Occurrence of Caligus asperimanus Pearse, 1951 (Copepoda: Caligidae) parasitic Lutjanus spp. (Perciformes: Lutjanidae) in the western South Atlantic.

Sea lice are widespread copepods in marine teleost around the world. In this paper the first record of Caligus asperimanus Pearse, 1951 in the Western South Atlantic is documented parasitizing Lutjanus jocu and Lutjanus vivanus caught from coastal zones of Espírito Santo and Rio de Janeiro State, respectively.

Consumption of latex from Euphorbia tirucalli L. promotes a reduction of tumor growth and cachexia, and immunomodulation in Walker 256 tumor-bearing rats.

Ethnopharmacological Relevance: Euphorbia tirucalli L. is an African plant that grows well in Brazil. Individuals diagnosed with cancer frequently consume latex from E.

Quality of sleep and use of computers and cell-phones among university students.

Objective: Evaluate the quality of sleep and its association with the use of computers and cell-phones among medicine and dentistry students.

Methods: Cross-sectional and comparative study, which evaluated 425 students through a socioeconomic questionnaire, the Pittsburgh Sleep Quality Index(PSQI), and a questionnaire on their use of computers and cell phones.

Results: Poor sleep quality was observed in 61.

Extrapelvic Endometriosis: A Systematic Review.

Objective: To conduct a systematic review of the literature on patients with extrapelvic deep endometriosis.

Data Sources: A thorough search of the PubMed/Medline, Embase, and Cochrane databases was performed.

Methods Of Study Selection: Studies in the last 20 years that reported on primary extrapelvic endometriosis were included (PROSPERO registration number CRD42019125370).

Which Knots Are Recommended in Laparoscopic Surgery and How to Avoid Insecure Knots.

Study Objective: To investigate why security of identical knot sequences is variable and how to avoid occasionally insecure knots.

Design: A factorial design was used to assess factors affecting the security of half knot (H) and half-hitch (S) knot combinations. The effect of tying forces and the risk factors to transform H knots into S knots were investigated.