Publications by authors named "Luiz F Viola"

Article Synopsis
  • - The study investigates familial partial lipodystrophy (FPLD) in Brazil, focusing on its clinical, metabolic, and genetic characteristics through a multicenter analysis involving 106 patients.
  • - Results show a high prevalence of diabetes (57.5%), severe hypertriglyceridemia (34.9%), metabolic-associated fatty liver disease (56.6%), and a notable mortality rate linked to cardiovascular issues (3.8%).
  • - The findings highlight the need for better understanding and management of FPLD, particularly due to the serious health complications associated with the disorder in this population.
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Article Synopsis
  • Lipodystrophies are disorders that cause the selective loss of fat tissue, leading to increased risks of insulin resistance and related health issues, particularly in women with familial partial lipodystrophy type 2 (FPLD2), who also often face complications with pregnancy and gynecological conditions like PCOS.
  • The study conducted a retrospective analysis of 8 women diagnosed with FPLD2 who had pregnancies, examining their pregnancy outcomes and associated complications.
  • Results indicated significant fetal complications, including high rates of gestational diabetes, preeclampsia, miscarriages, and other neonatal issues, although no cases of infertility were reported.
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Background: Lipodystrophies are a heterogeneous group of diseases characterized by the selective loss of subcutaneous adipose tissue and ectopic fat deposition in different organs, including the liver. This study aimed to determine the frequencies of liver steatosis (LS) and liver fibrosis (LF) in a sample of individuals with LMNA-related and unrelated Familial Partial Lipodystrophy.

Methods: This cross-sectional study included 17 women with LMNA-related FPLD and 15 women with unrelated FPLD.

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