Publications by authors named "Luiz Claudio Ferreira Pimentel"
The human immunodeficiency virus (HIV) produces the pathologic basis of acquired immunodeficiency syndrome (AIDS). An increase in the viral load in the body leads to a decline in the number of T lymphocytes, compromising the patient's immune system. Some opportunistic diseases may result, such as tuberculosis (TB), which is the most common in seropositive patients.
View Article and Find Full Text PDF(Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia.
Beilstein J Org Chem
September 2021
Article Synopsis
- The BCR-Abl-1 enzyme is crucial for treating chronic myeloid leukemia, and tyrosine kinase inhibitors like imatinib are used to inhibit it.
- Researchers developed twelve new compounds using a specific chemical group and tested their effectiveness against leukemia cells and healthy cells to assess selectivity.
- Three of these new compounds demonstrated significant inhibitory activity, showing potential to compete with imatinib for the same binding site on the BCR-Abl-1 enzyme.
The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI's with nano/picomolar activity.
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