Increased levels of interleukin-6, -8 and -10 are associated with fatal outcome following severe traumatic brain injury.

Background: Despite the involvement of cytokine production in neurotrauma, there is still controversy regarding cytokines levels and clinical outcome following severe traumatic brain injury (TBI).

Objective: The present study was designed to investigate whether cytokine levels (of IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α) are associated with primary outcome (death or survival) after severe TBI.

Methods: This prospective study enrolled 24 male patients, victims of severe TBI.